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Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans
Open accessAbstract
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy that bypasses normal regulatory mechanisms. By efficient gene targeting, we have replaced, en masse, the promoters of nonreducing polyketide synthase (NR-PKS) genes, key genes in NP biosynthetic pathways, and other genes necessary for NR-PKS product formation or release. This has allowed us to determine the products of eight NR-PKSs of Aspergillus nidulans, including seven novel compounds, as well as the NR-PKS genes required for the synthesis of the toxins alternariol (8) and cichorine (19).
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Cited by
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de Vries, R. P., Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Uchima, C. A., Anderluh, G., Asadollahi, M., Askin, M., Barry, K., et al. (2017) · Genome Biology · doi:10.1186/s13059-017-1151-0 · Cited by 489
Self-citationInglis, D. O., Binkley, J., Skrzypek, M. S., Arnaud, M. B., Cerqueira, G. C., Shah, P., Wymore, F., Wortman, J. R., & Sherlock, G. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-91 · Cited by 293
Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules
Chooi, Y.-H., & Tang, Y. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo301592k · Cited by 271
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Klitgaard, A., Nielsen, J. B., Frandsen, R. J. N., Andersen, M. R., & Nielsen, K. F. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01934 · Cited by 54
Metadata
- Authors
- Ahuja, M., Chiang, Y.-M., Chang, S.-L., Praseuth, M. B., Entwistle, R., Sanchez, J. F., Lo, H.-C., Yeh, H.-H., Oakley, B. R., & Wang, C. C. C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-01
- Volume
- 134
- Issue
- 19
- Pages
- 8212-8221
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2048022791
- Cited by
- 174
- References
- 0
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Ahuja, M., Chiang, Y.-M., Chang, S.-L., Praseuth, M. B., Entwistle, R., Sanchez, J. F., Lo, H.-C., Yeh, H.-H., Oakley, B. R., & Wang, C. C. C. (2012). Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans. Journal of the American Chemical Society. https://doi.org/10.1021/ja3016395
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