The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Sterilizable Gels from Thermoresponsive Block Copolymer Worms
Abstract
Biocompatible hydrogels have many applications, ranging from contact lenses to tissue engineering scaffolds. In most cases, rigorous sterilization is essential. Herein we show that a biocompatible diblock copolymer forms wormlike micelles via polymerization-induced self-assembly in aqueous solution. At a copolymer concentration of 10.0 w/w %, interworm entanglements lead to the formation of a free-standing physical hydrogel at 21 °C. Gel dissolution occurs on cooling to 4 °C due to an unusual worm-to-sphere order-order transition, as confirmed by rheology, electron microscopy, variable temperature (1)H NMR spectroscopy, and scattering studies. Moreover, this thermo-reversible behavior allows the facile preparation of sterile gels, since ultrafiltration of the diblock copolymer nanoparticles in their low-viscosity spherical form at 4 °C efficiently removes micrometer-sized bacteria; regelation occurs at 21 °C as the copolymer chains regain their wormlike morphology. Biocompatibility tests indicate good cell viabilities for these worm gels, which suggest potential biomedical applications.
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Cites
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 20,298
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Svergun, D. I. (1992) · Journal of Applied Crystallography · doi:10.1107/s0021889892001663 · Cited by 3,759
Hydrophilic gels for biological use
WICHTERLE, O., & LÍM, D. (1960) · Nature · doi:10.1038/185117a0 · Cited by 2,996
Shape effects of filaments versus spherical particles in flow and drug delivery
Geng, Y., Dalhaimer, P., Cai, S., Tsai, R., Tewari, M., Minko, T., & Discher, D. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.70 · Cited by 2,565
Zhang, L., & Eisenberg, A. (1995) · Science · doi:10.1126/science.268.5218.1728 · Cited by 2,477
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Silva, G. A., Czeisler, C., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,169
Biodegradable block copolymers as injectable drug-delivery systems
Jeong, B., Bae, Y. H., Lee, D. S., & Kim, S. W. (1997) · Nature · doi:10.1038/42218 · Cited by 1,997
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Self-citationA new method for the evaluation of small-angle scattering data
Glatter, O. (1977) · Journal of Applied Crystallography · doi:10.1107/s0021889877013879 · Cited by 1,279
Cited by
Design and applications of man-made biomimetic fibrillar hydrogels
Prince, E., & Kumacheva, E. (2019) · Nature Reviews Materials · doi:10.1038/s41578-018-0077-9 · Cited by 379
Rieger, J. (2015) · Macromolecular Rapid Communications · doi:10.1002/marc.201500028 · Cited by 349
Fonseca Parra, E. P., Oumerri, J., Arteni, A. A., Six, J.-L., Armes, S. P., & Ferji, K. (2025) · Macromolecules · doi:10.1021/acs.macromol.4c01772 · Cited by 8
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Metadata
- Authors
- Blanazs, A., Verber, R., Mykhaylyk, O. O., Ryan, A. J., Heath, J. Z., Douglas, C. W. I., & Armes, S. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-31
- Volume
- 134
- Issue
- 23
- Pages
- 9741-9748
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2095527210
- Cited by
- 396
- References
- 44
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blanazs, A., Verber, R., Mykhaylyk, O. O., Ryan, A. J., Heath, J. Z., Douglas, C. W. I., & Armes, S. P. (2012). Sterilizable Gels from Thermoresponsive Block Copolymer Worms. Journal of the American Chemical Society. https://doi.org/10.1021/ja3024059
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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