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Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release
Abstract
We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) "nanocarriers" for drug delivery; (ii) "phototriggers" for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery.
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Citations
Cited by
Yuan, Y., Kwok, R. T. K., Tang, B. Z., & Liu, B. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411811w · Cited by 474
Cai, Y., Liang, P., Tang, Q., Yang, X., Si, W., Huang, W., Zhang, Q., & Dong, X. (2017) · ACS Nano · doi:10.1021/acsnano.6b07927 · Cited by 422
Li, T., Yang, D., Zhai, L., Wang, S., Zhao, B., Fu, N., Wang, L., Tao, Y., & Huang, W. (2017) · Advanced Science · doi:10.1002/advs.201600166 · Cited by 138
Cheng, Y., Huang, F., Min, X., Gao, P., Zhang, T., Li, X., Liu, B., Hong, Y., Lou, X., & Xia, F. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02833 · Cited by 94
Metadata
- Authors
- Jana, A., Devi, K. S. P., Maiti, T. K., & Singh, N. D. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-24
- Volume
- 134
- Issue
- 18
- Pages
- 7656-7659
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2098199929
- Cited by
- 192
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release. https://app.cochat.ai/papers/10.1021/ja302482k
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- Jana, A., Devi, K. S. P., Maiti, T. K., & Singh, N. D. P. (2012). Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release. Journal of the American Chemical Society. https://doi.org/10.1021/ja302482k
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