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Chemical Molecule-Induced Light-Activated System for Anticancer and Antifungal Activities
Abstract
Except for chemotherapy, surgery, and radiotherapy, photodynamic therapy (PDT) as new therapy modality is already in wide clinic use for the treatment of various diseases. The major bottleneck of this technique is the requirement of outer light source, which always limits effective application of PDT to the lesions in deeper tissue. Here, we first report a new modality for treating cancer and microbial infections, which is activated by chemical molecules instead of outer light irradiation. In this system, in situ bioluminescence of luminol can be absorbed by a cationic oligo(p-phenylene vinylene) (OPV) that acts as the photosensitizer through bioluminescence resonance energy transfer (BRET) process. The excited OPV sensitizes oxygen molecule in the surroundings to produce reactive oxygen species (ROS) that kill the adjacent cancer cells in vitro and in vivo, and pathogenic microbes. By avoiding the use of light irradiation, this work opens a new therapy modality to tumor and pathogen infections.
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Gao, M., Yu, F., Lv, C., Choo, J., & Chen, L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00908e · Cited by 827
Phthalocyanines as medicinal photosensitizers: Developments in the last five years
Li, X., Zheng, B.-D., Peng, X.-H., Li, S.-Z., Ying, J.-W., Zhao, Y., Huang, J.-D., & Yoon, J. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.003 · Cited by 523
Organic photosensitizers for antimicrobial phototherapy
Nguyen, V.-N., Zhao, Z., Tang, B. Z., & Yoon, J. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00647a · Cited by 462
Rejuvenated Photodynamic Therapy for Bacterial Infections
Jia, Q., Song, Q., Li, P., & Huang, W. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900608 · Cited by 426
Metadata
- Authors
- Yuan, H., Chong, H., Wang, B., Zhu, C., Liu, L., Yang, Q., Lv, F., & Wang, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-02
- Volume
- 134
- Issue
- 32
- Pages
- 13184-13187
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2329574445
- Cited by
- 296
- References
- 0
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, H., Chong, H., Wang, B., Zhu, C., Liu, L., Yang, Q., Lv, F., & Wang, S. (2012). Chemical Molecule-Induced Light-Activated System for Anticancer and Antifungal Activities. Journal of the American Chemical Society. https://doi.org/10.1021/ja304986t
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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