Cited by 1,813Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, Thanh Chung, Nguyen, Van-Nghia, Choi, Yeonghwan, Lee, Songyi, Yoon, Juyoung·2021·Chemical Reviews

Abstract

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.

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Crossref · 10.1021/acs.chemrev.1c00381

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  • PDT utilizing next-generation metal-based photosensitizers with extended excitation and emission spectra holds significant promise for antibacterial applications.

    “PDT utilizing next-generation metal-based photosensitizers with extended excitation and emission spectra holds significant promise for antibacterial applications16,241.”
  • Phototoxicity from PDT is dependent on both oxygen tension and photosensitizer concentration.

    “This is a very important detail because phototoxicity from PDT is dependent on both oxygen tension and photosensitizer concentration. 440 , 441”

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Authors
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J.
Affiliations
  • Pukyong National University (KR)
  • Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
  • Ewha Womans University (KR)
Corresponding author
  • Lee, Songyi
  • Yoon, Juyoung
Venue
Chemical Reviews
Published
2021-09-28
Volume
121
Issue
21
Pages
13454-13619
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W3204360553
Cited by
1,813
References
1,199
Citations by year
2026: 308 · 2025: 457 · 2024: 466 · 2023: 338 · 2022: 240 · 2021: 4
FWCI
42.14
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (2012R1A3A2048814, 2017R1A6A3A04004954, 2021R1A6A1A10039823)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords
photosensitizers, photodynamic therapy, organic photosensitizers, reactive oxygen species, cancer therapy, rational design
MeSH terms
Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents, Reactive Oxygen Species, Nanotechnology

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