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Cited by 187

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Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties

Huynh, Elizabeth, Lovell, Jonathan F., Helfield, Brandon L., Jeon, Mansik, Kim, Chulhong, Goertz, David E., Wilson, Brian C., Zheng, Gang·2012·Journal of the American Chemical Society

Abstract

Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.

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Metadata

Authors
Huynh, E., Lovell, J. F., Helfield, B. L., Jeon, M., Kim, C., Goertz, D. E., Wilson, B. C., & Zheng, G.
Venue
Journal of the American Chemical Society
Published
2012-08-01
Volume
134
Issue
40
Pages
16464-16467
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W1980785302
Cited by
187
References
0
FWCI
10.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties. https://app.cochat.ai/papers/10.1021/ja305988f
The paper
Huynh, E., Lovell, J. F., Helfield, B. L., Jeon, M., Kim, C., Goertz, D. E., Wilson, B. C., & Zheng, G. (2012). Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties. Journal of the American Chemical Society. https://doi.org/10.1021/ja305988f

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