Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation
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Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO‐MB are destroyed, resulting in acoustic forces inducing vessel permeability. At the same time, USPIO are released from the MB shell, they extravasate across the permeabilized BBB and they accumulate in extravascular brain tissue, thereby providing non‐invasive R 2*‐based magnetic resonance imaging information on the extent of BBB opening. Quantitative changes in R 2* relaxometry are in good agreement with 2D and 3D microscopy results on the extravascular deposition of the macromolecular model drug fluorescein isothiocyanate (FITC)‐dextran into the brain. Such theranostic materials and methods are considered to be useful for mediating and monitoring drug delivery across the BBB and for enabling safe and efficient treatment of CNS disorders.
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The use of ultrasound and microbubbles increases the permeability of vascular endothelium and cellular membranes through sonoporation, thereby promoting uptake of therapeutic compounds at target sites and in target cells.
“In case of indirect drug delivery, the use of US and MB increases the permeability of vascular endothelium and cellular membranes, through a process called sonoporation, thereby promoting the uptake of therapeutic compounds at target sites and in target cells [247, 248].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [247]
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- Authors
- Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F.
- Affiliations
- Utrecht University (NL)
- Universitätsklinikum Aachen (DE)
- DWI – Leibniz Institute for Interactive Materials (DE)
- Institute for Molecular Cardiovascular Research (IMCAR) University Clinic RWTH Aachen University Aachen Germany
- Corresponding author
- Lammers, Twan
- Koczera, Patrick
- Kiessling, Fabian
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2014-09-16
- Volume
- 25
- Issue
- 1
- Pages
- 36-43
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- PMC
- PMC4340520
- OpenAlex
- W1983961577
- Cited by
- 156
- References
- 33
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 16 · 2021: 20 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 16 · 2016: 20 · 2015: 9
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advanced Functional Materials (publishedVersion)
- PubMed (publishedVersion)
- University of Twente Research Information (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- University of Twente Research Information (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- European Commission (2007–2013, 310451)
- Deutsche Forschungsgemeinschaft (309495, LA2937/1-2)
- RWTH Aachen University
- European Regional Development Fund (2007 – 2013)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- blood-brain barrier permeability, microbubbles, ultrasmall superparamagnetic iron oxide, poly(butyl cyanoacrylate), transcranial ultrasound, theranostics, R2* relaxometry, FITC-dextran, central nervous system disorders
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