The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Amine-Functionalized Lanthanide-Doped Zirconia Nanoparticles: Optical Spectroscopy, Time-Resolved Fluorescence Resonance Energy Transfer Biodetection, and Targeted Imaging
Abstract
Ultrasmall inorganic oxide nanoparticles doped with trivalent lanthanide ions (Ln(3+)), a new and huge family of luminescent bioprobes, remain nearly untouched. Currently it is a challenge to synthesize biocompatible ultrasmall oxide bioprobes. Herein, we report a new inorganic oxide bioprobe based on sub-5 nm amine-functionalized tetragonal ZrO(2)-Ln(3+) nanoparticles synthesized via a facile solvothermal method and ligand exchange. By utilizing the long-lived luminescence of Ln(3+), we demonstrate its application as a sensitive time-resolved fluorescence resonance energy transfer (FRET) bioprobe to detect avidin with a record-low detection limit of 3.0 nM. The oxide nanoparticles also exhibit specific recognition of cancer cells overexpressed with urokinase plasminogen activator receptor (uPAR, an important marker of tumor biology and metastasis) and thus may have great potentials in targeted bioimaging.
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Cites
Multigram Scale Synthesis and Characterization of Monodisperse Tetragonal Zirconia Nanocrystals
Joo, J., Yu, T., Kim, Y. W., Park, H. M., Wu, F., Zhang, J. Z., & Hyeon, T. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034258b · Cited by 412
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Self-citationAn overview of nanoparticles commonly used in fluorescent bioimaging
Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631
Gu, B., & Zhang, Q. (2018) · Advanced Science · doi:10.1002/advs.201700609 · Cited by 292
Upconversion luminescence imaging of cells and small animals
Liu, Q., Feng, W., Yang, T., Yi, T., & Li, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.114 · Cited by 291
Li, L.-L., Wu, P., Hwang, K., & Lu, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja310432u · Cited by 280
Metadata
- Authors
- Liu, Y., Zhou, S., Tu, D., Chen, Z., Huang, M., Zhu, H., Ma, E., & Chen, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-30
- Volume
- 134
- Issue
- 36
- Pages
- 15083-15090
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2017344058
- Cited by
- 241
- References
- 1
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Y., Zhou, S., Tu, D., Chen, Z., Huang, M., Zhu, H., Ma, E., & Chen, X. (2012). Amine-Functionalized Lanthanide-Doped Zirconia Nanoparticles: Optical Spectroscopy, Time-Resolved Fluorescence Resonance Energy Transfer Biodetection, and Targeted Imaging. Journal of the American Chemical Society. https://doi.org/10.1021/ja306066a
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