The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging
Open accessAbstract
Lanthanide-doped up-conversion nanoparticles (UCNPs) have shown promise in biomedical applications. However, as the UCNPs are normally capped with hydrophobic ligands, it remains challenging to prepare biocompatible UCNPs with specific molecular recognition capabilities. We herein report an exceptionally simple strategy to prepare uniform DNA-modified UCNPs as versatile bioprobes. The approach can directly convert as-prepared hydrophobic UCNPs into water-soluble DNA-UCNPs without any chemical modification of UCNPs or oligonucleotides. Furthermore, DNA molecules on the DNA-UCNPs retain their biorecognition ability, allowing programmable assembly of hybrid nanostructures. More importantly, we show that these DNA-UCNPs are capable of crossing cell membranes without the need of transfection agents, and their use as agents for bioimaging and DNA delivery are also demonstrated. Finally, DNA aptamer-conjugated UCNPs can be readily used for targeted imaging of cancer cells.
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Cites
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Self-citationRecent advances in the chemistry of lanthanide-doped upconversion nanocrystals
Wang, F., & Liu, X. (2009) · Chemical Society Reviews · doi:10.1039/b809132n · Cited by 3,004
Organization of 'nanocrystal molecules' using DNA
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Self-citationOligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
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NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 451
Min, Y., Li, J., Liu, F., Yeow, E. K. L., & Xing, B. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308834 · Cited by 309
The biosafety of lanthanide upconversion nanomaterials
Sun, Y., Feng, W., Yang, P., Huang, C., & Li, F. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00175c · Cited by 309
Metadata
- Authors
- Li, L.-L., Wu, P., Hwang, K., & Lu, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-07
- Volume
- 135
- Issue
- 7
- Pages
- 2411-2414
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2011928788
- Cited by
- 280
- References
- 48
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, L.-L., Wu, P., Hwang, K., & Lu, Y. (2013). An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging. Journal of the American Chemical Society. https://doi.org/10.1021/ja310432u
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