The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ultra-Small, Highly Stable, and Sensitive Dual Nanosensors for Imaging Intracellular Oxygen and pH in Cytosol
Abstract
We report on the first dual nanosensors for imaging of pH values and oxygen partial pressure in cells. The sensors have a unique nanostructure in that a soft core structure is rigidized with a silane reagent, while poly(ethylene glycol) chains form an outer shell. Lipophilic oxygen-sensitive probes and reference dyes are encapsulated inside the hydrophobic core, while a pH-sensitive probe is covalently attached to the poly(ethylene glycol) end-group on the shell. The core/shell structure renders the nanosensors well dispersed and highly stable in various kinds of aqueous media. Their average size is 12 nm, and they respond to both pH and oxygen in the physiological range. They do not pass cell membranes, but can be internalized into the cellular cytosol by electroporation, upon which they enable sensing and imaging of pH values and oxygen with high spatial resolution. The nanosensor strategy shown here is expected to be applicable to the development of various other kinds of multiple nanosensors for in vivo studies.
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Hell, S. W. (2007) · Science · doi:10.1126/science.1137395 · Cited by 2,967
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704
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Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631
Self-citationOptical methods for sensing and imaging oxygen: materials, spectroscopies and applications
Wang, X.-D., & Wolfbeis, O. S. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00039k · Cited by 1,114
Self-citationZheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications
Steinegger, A., Wolfbeis, O. S., & Borisov, S. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00451 · Cited by 622
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Metadata
- Authors
- Wang, X.-D., Stolwijk, J. A., Lang, T., Sperber, M., Meier, R. J., Wegener, J., & Wolfbeis, O. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-10-01
- Volume
- 134
- Issue
- 41
- Pages
- 17011-17014
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1978988063
- Cited by
- 223
- References
- 2
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- closed
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