The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine
Abstract
We report a ratiometric fluorescent sensor based on monochlorinated BODIPY for highly selective detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy). The chlorine of the monochlorinated BODIPY can be rapidly replaced by thiolates of biothiols through thiol-halogen nucleophilic substitution. The amino groups of Cys/Hcy but not GSH further replace the thiolate to form amino-substituted BODIPY. The significantly different photophysical properties of sulfur- and amino-substituted BODIPY enable the discrimination of GSH over Cys and Hcy. The sensor was applied for detection of GSH in living cells.
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Citations
Cites
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
Loudet, A., & Burgess, K. (2007) · Chemical Reviews · doi:10.1021/cr078381n · Cited by 5,238
Fluorescent and colorimetric probes for detection of thiols
Chen, X., Zhou, Y., Peng, X., & Yoon, J. (2010) · Chemical Society Reviews · doi:10.1039/b925092a · Cited by 1,580
Cited by
BODIPY-based probes for the fluorescence imaging of biomolecules in living cells
Kowada, T., Maeda, H., & Kikuchi, K. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00030k · Cited by 1,381
Applications of Supramolecular Anion Recognition
Busschaert, N., Caltagirone, C., Van Rossom, W., & Gale, P. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00099 · Cited by 1,249
Design strategies of fluorescent probes for selective detection among biothiols
Niu, L.-Y., Chen, Y.-Z., Zheng, H.-R., Wu, L.-Z., Tung, C.-H., & Yang, Q.-Z. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00152h · Cited by 870
Self-citationActivatable Photosensitizers: Agents for Selective Photodynamic Therapy
Li, X., Kolemen, S., Yoon, J., & Akkaya, E. U. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604053 · Cited by 544
Umezawa, K., Yoshida, M., Kamiya, M., Yamasoba, T., & Urano, Y. (2017) · Nature Chemistry · doi:10.1038/nchem.2648 · Cited by 508
Metadata
- Authors
- Niu, L.-Y., Guan, Y.-S., Chen, Y.-Z., Wu, L.-Z., Tung, C.-H., & Yang, Q.-Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-11-08
- Volume
- 134
- Issue
- 46
- Pages
- 18928-18931
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1983847563
- Cited by
- 901
- References
- 2
- FWCI
- 24.99
- Type
- journal article
- Language
- en
- Open access
- closed
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