The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
d -Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Nonsteroidal Anti-Inflammatory Drug (NSAID)
Open accessAbstract
As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. Thus, it is beneficial to develop topical gels that selectively inhibit cyclooxygenase-2 (COX-2) for the management of local inflammation. In this work, we demonstrate that the covalent conjugation of d-amino acids to naproxen (i.e., a NSAID) not only affords supramolecular hydrogelators for the topical gels but also unexpectedly and significantly elevates the selectivity toward COX-2 about 20× at little expense of the activity of naproxen. This work illustrates a previously unexplored approach that employs d-amino acids for the development of functional molecules that have dual or multiple roles and exceptional biostability, which offers a new class of molecular hydrogels of therapeutic agents.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
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Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
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Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
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Cited by
Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery
Merino, S., Martín, C., Kostarelos, K., Prato, M., & Vázquez, E. (2015) · ACS Nano · doi:10.1021/acsnano.5b01433 · Cited by 801
Cheetham, A. G., Chakroun, R. W., Ma, W., & Cui, H. (2017) · Chem. Soc. Rev. · doi:10.1039/c7cs00521k · Cited by 367
Supramolecular hydrogels: synthesis, properties and their biomedical applications
Dong, R., Pang, Y., Su, Y., & Zhu, X. (2015) · Biomaterials Science · doi:10.1039/c4bm00448e · Cited by 302
Self-assemble peptide biomaterials and their biomedical applications
Chen, J., & Zou, X. (2019) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.01.002 · Cited by 257
Tesauro, D., Accardo, A., Diaferia, C., Milano, V., Guillon, J., Ronga, L., & Rossi, F. (2019) · Molecules · doi:10.3390/molecules24020351 · Cited by 225
Metadata
- Authors
- Li, J., Kuang, Y., Gao, Y., Du, X., Shi, J., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-11-14
- Volume
- 135
- Issue
- 2
- Pages
- 542-545
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2024829972
- Cited by
- 283
- References
- 5
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
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