The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Long-Term Fluorescent Cellular Tracing by the Aggregates of AIE Bioconjugates
Abstract
There is a great demand for long-term cellular tracers because of their great importance in monitoring biological processes, pathological pathways, therapeutic effects, etc. Herein we report a new type of fluorescence "turn-on" probe for tracing live cells over a long period of time. We synthesized the fluorogenic probe by attaching a large number of tetraphenylethene (TPE) labels to a chitosan (CS) chain. The resultant TPE-CS bioconjugate shows a unique aggregation-induced emission (AIE) behavior. It is nonfluorescent when dissolved but becomes highly emissive when its molecules are aggregated. The AIE aggregates can be readily internalized by HeLa cells. The cellular staining by the TPE-CS aggregates is so indelible that it enables cell tracing for as long as 15 passages. The internalized AIE aggregates are kept inside the cellular compartments and do not contaminate other cell lines in the coculture systems, permitting the differentiation of specific cancerous cells from normal healthy cells.
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Citations
Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Self-citationHong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
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Cited by
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationPolymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging
Li, K., & Liu, B. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00014e · Cited by 987
Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging
Reisch, A., & Klymchenko, A. S. (2016) · Small · doi:10.1002/smll.201503396 · Cited by 634
Polymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives
Zhang, X., Wang, K., Liu, M., Zhang, X., Tao, L., Chen, Y., & Wei, Y. (2015) · Nanoscale · doi:10.1039/c5nr01444a · Cited by 508
Progress and Trends in AIE-Based Bioprobes: A Brief Overview
Mei, J., Huang, Y., & Tian, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14343 · Cited by 384
Metadata
- Authors
- Wang, Z., Chen, S., Lam, J. W. Y., Qin, W., Kwok, R. T. K., Xie, N., Hu, Q., & Tang, B. Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-05-22
- Volume
- 135
- Issue
- 22
- Pages
- 8238-8245
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2004641708
- Cited by
- 368
- References
- 2
- FWCI
- 21.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Z., Chen, S., Lam, J. W. Y., Qin, W., Kwok, R. T. K., Xie, N., Hu, Q., & Tang, B. Z. (2013). Long-Term Fluorescent Cellular Tracing by the Aggregates of AIE Bioconjugates. Journal of the American Chemical Society. https://doi.org/10.1021/ja312581r
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