The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Progress and Trends in AIE-Based Bioprobes: A Brief Overview
Abstract
Luminescent bioprobes are powerful analytical means for biosensing and optical imaging. Luminogens featured with aggregation-induced emission (AIE) attributes have emerged as ideal building blocks for high-performance bioprobes. Bioprobes constructed with AIE luminogens have been identified to be a novel class of FL light-up probing tools. In contrast to conventional bioprobes based on the luminophores with aggregation-caused quenching (ACQ) effect, the AIE-based bioprobes enjoy diverse superiorities, such as lower background, higher signal-to-noise ratio and sensitivity, better accuracy, and more outstanding resistance to photobleaching. AIE-based bioprobes have been tailored for a vast variety of purposes ranging from biospecies sensing to bioimaging to theranostics (i.e., image-guided therapies). In this review, recent five years' advances in AIE-based bioprobes are briefly overviewed in a perspective distinct from other reviews, focusing on the most appealing trends and progresses in this flourishing research field. There are altogether 11 trends outlined, which have been classified into four aspects: the probe composition and form (bioconjugtes, nanoprobes), the output signal of probe (far-red/near-infrared luminescence, two/three-photon excited fluorescence, phosphorescence), the modality and functionality of probing system (dual-modality, dual/multifunctionality), the probing object and application outlet (specific organelles, cancer cells, bacteria, real samples). Typical examples of each trend are presented and specifically demonstrated. Some important prospects and challenges are pointed out as well in the hope of intriguing more interests from researchers working in diverse areas into this exciting research field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationPhotophysics of aromatic molecules
Sharnoff, M. (1971) · Journal of Luminescence · doi:10.1016/0022-2313(71)90011-1 · Cited by 4,482
Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,381
Self-citationPhotophysics of aromatic molecules
Birks, J. B. (1970) · Cited by 3,363
Bioprobes Based on AIE Fluorogens
Ding, D., Li, K., Liu, B., & Tang, B. Z. (2013) · Accounts of Chemical Research · doi:10.1021/ar3003464 · Cited by 1,817
Upconversion nanophosphors for small-animal imaging
Zhou, J., Liu, Z., & Li, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15187h · Cited by 1,581
Controlling upconversion nanocrystals for emerging applications
Zhou, B., Shi, B., Jin, D., & Liu, X. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.251 · Cited by 1,503
Biosensing by luminogens with aggregation-induced emission characteristics
Kwok, R. T. K., Leung, C. W. T., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00325j · Cited by 1,296
Chen, J., Law, C. C. W., Lam, J. W. Y., Dong, Y., Lo, S. M. F., Williams, I. D., Zhu, D., & Tang, B. Z. (2003) · Chemistry of Materials · doi:10.1021/cm021715z · Cited by 1,190
Cited by
Aggregation-Induced Emission Luminogens for Activity-Based Sensing
Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Rejuvenated Photodynamic Therapy for Bacterial Infections
Jia, Q., Song, Q., Li, P., & Huang, W. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900608 · Cited by 426
Yao, D., Wang, Y., Zou, R., Bian, K., Liu, P., Shen, S., Yang, W., Zhang, B., & Wang, D. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20147 · Cited by 151
A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes
Luo, X., Li, J., Zhao, J., Gu, L., Qian, X., & Yang, Y. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.03.012 · Cited by 119
Metadata
- Authors
- Mei, J., Huang, Y., & Tian, H.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-11-15
- Volume
- 10
- Issue
- 15
- Pages
- 12217-12261
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2769269523
- Cited by
- 384
- References
- 196
- FWCI
- 19.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Progress and Trends in AIE-Based Bioprobes: A Brief Overview. https://app.cochat.ai/papers/10.1021/acsami.7b14343
- The paper
- Mei, J., Huang, Y., & Tian, H. (2018). Progress and Trends in AIE-Based Bioprobes: A Brief Overview. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.7b14343
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
