The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antimicrobial Metallopolymers and Their Bioconjugates with Conventional Antibiotics against Multidrug-Resistant Bacteria
Abstract
Bacteria are now becoming more resistant to most conventional antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA), a complex of multidrug-resistant Gram-positive bacterial strains, has proven especially problematic in both hospital and community settings by deactivating conventional β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, through various mechanisms, resulting in increased mortality rates and hospitalization costs. Here we introduce a class of charged metallopolymers that exhibit synergistic effects against MRSA by efficiently inhibiting activity of β-lactamase and effectively lysing bacterial cells. Various conventional β-lactam antibiotics, including penicillin-G, amoxicillin, ampicillin, and cefazolin, are protected from β-lactamase hydrolysis via the formation of unique ion-pairs between their carboxylate anions and cationic cobaltocenium moieties. These discoveries could provide a new pathway for designing macromolecular scaffolds to regenerate vitality of conventional antibiotics to kill multidrug-resistant bacteria and superbugs.
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Citations
Cites
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Three Decades of β-Lactamase Inhibitors
Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709
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Cao, F., Zhang, L., You, Y., Zheng, L., Ren, J., & Qu, X. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201912182 · Cited by 319
Biomimetic antimicrobial polymers: recent advances in molecular design
Ergene, C., Yasuhara, K., & Palermo, E. F. (2018) · Polymer Chemistry · doi:10.1039/c8py00012c · Cited by 312
Metal-containing and related polymers for biomedical applications
Yan, Y., Zhang, J., Ren, L., & Tang, C. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00026f · Cited by 283
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Metadata
- Authors
- Zhang, J., Chen, Y. P., Miller, K. P., Ganewatta, M. S., Bam, M., Yan, Y., Nagarkatti, M., Decho, A. W., & Tang, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-20
- Volume
- 136
- Issue
- 13
- Pages
- 4873-4876
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2325628002
- Cited by
- 216
- References
- 2
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, J., Chen, Y. P., Miller, K. P., Ganewatta, M. S., Bam, M., Yan, Y., Nagarkatti, M., Decho, A. W., & Tang, C. (2014). Antimicrobial Metallopolymers and Their Bioconjugates with Conventional Antibiotics against Multidrug-Resistant Bacteria. Journal of the American Chemical Society. https://doi.org/10.1021/ja5011338
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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