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Nucleic Acid–Metal Organic Framework (MOF) Nanoparticle Conjugates
Abstract
Nanoparticles of a metal-organic framework (MOF), UiO-66-N3 (Zr6O4OH4(C8H3O4-N3)6), were synthesized. The surface of the MOF was covalently functionalized with oligonucleotides, utilizing a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionalized UiO-66-N3 to create the first MOF nanoparticle-nucleic acid conjugates. The structure of the framework was preserved throughout the chemical transformation, and the surface coverage of DNA was quantified. Due to the small pore sizes, the particles are only modified on their surfaces. When dispersed in aqueous NaCl, they exhibit increased stability and enhanced cellular uptake when compared with unfunctionalized MOF particles of comparable size.
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He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
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Park, J., Jiang, Q., Feng, D., Mao, L., & Zhou, H.-C. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b00007 · Cited by 915
Metal–organic frameworks for membrane-based separations
Denny, M. S., Moreton, J. C., Benz, L., & Cohen, S. M. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.78 · Cited by 820
Application of zirconium MOFs in drug delivery and biomedicine
Abánades Lázaro, I., & Forgan, R. S. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.009 · Cited by 678
Metal–Organic Frameworks for Food Safety
Wang, P.-L., Xie, L.-H., Joseph, E. A., Li, J.-R., Su, X.-O., & Zhou, H.-C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00257 · Cited by 533
Metadata
- Authors
- Morris, W., Briley, W. E., Auyeung, E., Cabezas, M. D., & Mirkin, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-05-12
- Volume
- 136
- Issue
- 20
- Pages
- 7261-7264
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2091385634
- Cited by
- 478
- References
- 1
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
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