The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Application of zirconium MOFs in drug delivery and biomedicine
Open accessAbstract
Abstract Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.
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Cited by
Winarta, J., Shan, B., Mcintyre, S. M., Ye, L., Wang, C., Liu, J., & Mu, B. (2020) · Crystal Growth & Design · doi:10.1021/acs.cgd.9b00955 · Cited by 641
Abdelhamid, H. N., & Mathew, A. P. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214263 · Cited by 341
Biocompatibility and biodegradability of metal organic frameworks for biomedical applications
Singh, N., Qutub, S., & Khashab, N. M. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01044a · Cited by 303
Yan, Y., Li, C., Wu, Y., Gao, J., & Zhang, Q. (2020) · Journal of Materials Chemistry A · doi:10.1039/d0ta03749d · Cited by 260
Metadata
- Authors
- Abánades Lázaro, I., & Forgan, R. S.
- Venue
- Coordination Chemistry Reviews
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 380
- Pages
- 230-259
- ISSN
- 0010-8545 (ISSN-L)
- OpenAlex
- W2898522442
- Cited by
- 678
- References
- 133
- FWCI
- 22.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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