The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission
Abstract
The development of a highly selective and fast responsive fluorogenic biosensor for diverse analytes ranging from bioactive small molecules to specific antigens is highly desirable but remains a considerable challenge. We herein propose a new approach by integrating substrate-selective enzymatic reactions with fluorogens exhibiting aggregation-induced emission feature. Tyrosine-functionalized tetraphenylethene, TPE-Tyr, molecularly dissolves in aqueous media with negligible fluorescence emission; upon addition of horseradish peroxidase (HRP) and H2O2, effective cross-linking occurs due to HRP-catalyzed oxidative coupling of tyrosine moieties in TPE-Tyr. This leads to fluorescence emission turn-on and fast detection of H2O2 with high sensitivity and selectivity. As a validation of the new strategy's generality, we further configure it into the biosensor design for glucose through cascade enzymatic reactions and for pathologically relevant antigens (e.g., human carcinoembryonic antigen) by combining with the ELISA kit.
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Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Chemistry and biology of reactive oxygen species in signaling or stress responses
Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821
Xue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., et al. (2014) · Advanced Materials · doi:10.1002/adma.201302365 · Cited by 206
Cited by
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Polymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives
Zhang, X., Wang, K., Liu, M., Zhang, X., Tao, L., Chen, Y., & Wei, Y. (2015) · Nanoscale · doi:10.1039/c5nr01444a · Cited by 508
Aggregation‐Induced Dual‐Phosphorescence from Organic Molecules for Nondoped Light‐Emitting Diodes
Wang, T., Su, X., Zhang, X., Nie, X., Huang, L., Zhang, X., Sun, X., Luo, Y., & Zhang, G. (2019) · Advanced Materials · doi:10.1002/adma.201904273 · Cited by 276
Self-citationSugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications
Wang, Y., Nie, J., Fang, W., Yang, L., Hu, Q., Wang, Z., Sun, J. Z., & Tang, B. Z. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00814 · Cited by 258
Metadata
- Authors
- Wang, X., Hu, J., Zhang, G., & Liu, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-07-08
- Volume
- 136
- Issue
- 28
- Pages
- 9890-9893
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2330238345
- Cited by
- 246
- References
- 4
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- closed
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