Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation‐Induced Emission
Abstract
Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.
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- Authors
- Xue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., Chen, W., Zou, G., & Liang, X.
- Affiliations
- National Center for Nanoscience and Technology (CN)
- Beijing University of Technology (CN)
- Institute of Modern Physics Chinese Academy of Sciences Nanchang Rd Lanzhou 730000 China
- Corresponding author
- Zou, Guozhang
- Liang, Xing‐Jie
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2013-10-16
- Volume
- 26
- Issue
- 5
- Pages
- 712-717
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2044008891
- Cited by
- 206
- References
- 29
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 14 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 15 · 2018: 29 · 2017: 21 · 2016: 18 · 2015: 29 · 2014: 13 · 2013: 1 · 2012: 1
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- spatiotemporal drug release, aggregation-induced emission, tetraphenylethylene, doxorubicin, fluorescent nanoparticles, lysosomal degradation
- MeSH terms
- Cell Survival, Doxorubicin, Drug Carriers, Humans, Hydrogen-Ion Concentration, Nanoparticles, MCF-7 Cells
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