Cited by 206Nanoparticle-Based Drug DeliveryLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranostics

Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation‐Induced Emission

Xue, Xiangdong, Zhao, Yuanyuan, Dai, Luru, Zhang, Xu, Hao, Xiaohong, Zhang, Chunqiu, Huo, Shuaidong, Liu, Juan +5 more·2014·Advanced Materials

Abstract

Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.

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Registry

Crossref · 10.1002/adma.201302365

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29 of 29 references verified0 citation errors · 0 not checkable

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Authors
Xue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., Chen, W., Zou, G., & Liang, X.
Affiliations
  • National Center for Nanoscience and Technology (CN)
  • Beijing University of Technology (CN)
  • Institute of Modern Physics Chinese Academy of Sciences Nanchang Rd Lanzhou 730000 China
Corresponding author
  • Zou, Guozhang
  • Liang, Xing‐Jie
Venue
Advanced Materials
Publisher
Wiley
Published
2013-10-16
Volume
26
Issue
5
Pages
712-717
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2044008891
Cited by
206
References
29
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 14 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 15 · 2018: 29 · 2017: 21 · 2016: 18 · 2015: 29 · 2014: 13 · 2013: 1 · 2012: 1
FWCI
7.77
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
spatiotemporal drug release, aggregation-induced emission, tetraphenylethylene, doxorubicin, fluorescent nanoparticles, lysosomal degradation
MeSH terms
Cell Survival, Doxorubicin, Drug Carriers, Humans, Hydrogen-Ion Concentration, Nanoparticles, MCF-7 Cells

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