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Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ-Forming Hydrogels for Cell Encapsulation
Abstract
The use of tough hydrogels as biomaterials is limited as a consequence of time-consuming fabrication techniques, toxic starting materials, and large strain hysteresis under deformation. Herein, we report the simultaneous application of nucleophilic thiol-yne and inverse electron-demand Diels-Alder additions to independently create two interpenetrating networks in a simple one-step procedure. The resultant hydrogels display compressive stresses of 14-15 MPa at 98% compression without fracture or hysteresis upon repeated load. The hydrogel networks can be spatially and temporally postfunctionalized via radical thiylation and/or inverse electron-demand Diels-Alder addition to residual functional groups within the network. Furthermore, gelation occurs rapidly under physiological conditions, enabling encapsulation of human cells.
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Cites
Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
Lowe, A. B. (2010) · Polym. Chem. · doi:10.1039/b9py00216b · Cited by 1,563
“Nonswellable” Hydrogel Without Mechanical Hysteresis
Kamata, H., Akagi, Y., Kayasuga-Kariya, Y., Chung, U.-I., & Sakai, T. (2014) · Science · doi:10.1126/science.1247811 · Cited by 669
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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications
Feng, W., & Wang, Z. (2023) · Advanced Science · doi:10.1002/advs.202303326 · Cited by 548
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Brown, T. E., & Anseth, K. S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00445a · Cited by 428
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Chemical strategies to engineer hydrogels for cell culture
Lou, J., & Mooney, D. J. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00420-7 · Cited by 386
Song, P., Ye, D., Zuo, X., Li, J., Wang, J., Liu, H., Hwang, M. T., Chao, J., Su, S., Wang, L., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b01006 · Cited by 258
Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Jia, Z., Xu, X., Zhu, D., & Zheng, Y. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101072 · Cited by 176
Chen, Z., Chen, M., Cheng, Y., Kowada, T., Xie, J., Zheng, X., & Rao, J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201913314 · Cited by 71
Metadata
- Authors
- Truong, V. X., Ablett, M. P., Richardson, S. M., Hoyland, J. A., & Dove, A. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-26
- Volume
- 137
- Issue
- 4
- Pages
- 1618-1622
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1974307925
- Cited by
- 214
- References
- 2
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- closed
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