Design Challenges in Polymeric Scaffolds for Tissue Engineering

Echeverria Molina, Maria I.; Malollari, Katerina G.; Komvopoulos, Kyriakos

doi:10.3389/fbioe.2021.617141

Cited by 397Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications

Design Challenges in Polymeric Scaffolds for Tissue Engineering

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Echeverria Molina, Maria I., Malollari, Katerina G., Komvopoulos, Kyriakos·2021·Frontiers in Bioengineering and Biotechnology

DOI 10.3389/fbioe.2021.617141PMC PMC8236583

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Abstract

Numerous surgical procedures are daily performed worldwide to replace and repair damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged tissue through the incorporation of cells in biocompatible and biodegradable porous constructs, known as scaffolds. The scaffolds act as host biomaterials of the incubating cells, guiding their attachment, growth, differentiation, proliferation, phenotype, and migration for the development of new tissue. Furthermore, cellular behavior and fate are bound to the biodegradation of the scaffold during tissue generation. This article provides a critical appraisal of how key biomaterial scaffold parameters, such as structure architecture, biochemistry, mechanical behavior, and biodegradability, impart the needed morphological, structural, and biochemical cues for eliciting cell behavior in various tissue engineering applications. Particular emphasis is given on specific scaffold attributes pertaining to skin and brain tissue generation, where further progress is needed (skin) or the research is at a relatively primitive stage (brain), and the enumeration of some of the most important challenges regarding scaffold constructs for tissue engineering.

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This can be related to the fact that fabricated materials were mainly developed as biologically inert, so they would not have provoked any reaction from the recipient's side.
“This can be related to the fact that fabricated materials were mainly developed as biologically inert, so they would not have provoked any reaction from the recipient’s side [199].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
The Immunomodulation section says that immune responses were historically treated as challenges and that biomaterial design has shifted from suppressing the immune response to actively modulating it. It does not say fabricated materials were mainly designed to be biologically inert or that they would provoke no reaction in recipients; it describes biomaterials as foreign bodies that elicit immune-mediated tissue reactions. No page number is available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Although many scaffolds have been successfully applied in vivo or utilized in clinical medicine to restore damaged tissues, adverse effects such as extensive inflammatory response leading to transplant rejection were often observed.
“Although many scaffolds have been successfully applied in vivo or utilized in clinical medicine to restore damaged tissues, adverse effects such as extensive inflammatory response leading to transplant rejection were often observed.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
The Introduction says some engineered tissues have been approved for human use, but transplantation can be limited by complications leading to biomaterial rejection. The Immunomodulation section describes inflammatory responses to implanted scaffolds and says immune reactions usually restrict transplant integration. It does not establish that many scaffolds have been successfully used clinically or that extensive inflammation leading to rejection was often observed. (LLM, conf=0.84)
Experimental — accuracy not yet measured
The synthetic material's prolonged presence causes an inflammatory response mediated by phagocytes and foreign body giant cells.
“Furthermore, the synthetic material’s prolonged presence causes an inflammatory response mediated by phagocytes and foreign body giant cells.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
The Immunomodulation section says implanted biomaterials can provoke an immune-mediated foreign-body reaction and describes inflammatory macrophages and phagocytes. It does not say that prolonged presence of synthetic material causes this response, or identify foreign body giant cells as mediators; that term appears only in a reference title. No page numbers are available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
The implantation site and the procedure of scaffold implantation affect the recruitment and composition of adjacent cell populations.
“The implantation site, as well as the procedure of scaffold implantation itself, affect the recruitment and composition of adjacent cell populations.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]
The Immunomodulation section says scaffold properties can affect immune-cell recruitment and the phenotype of infiltrating cells. But passages found when searching for implantation site and implantation procedure do not say that either the site or the procedure affects the recruitment and composition of adjacent cell populations. Our copy therefore does not establish the claim's stated causes. (LLM, conf=0.72)
Experimental — accuracy not yet measured
By-effects of this phenomenon include fibrous encapsulation of the implanted scaffold.
“By-effects of this phenomenon include fibrous encapsulation of the implanted scaffold [199].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [199]

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Advances in natural biomaterials for nerve tissue repair
Khaing, Z. Z., & Schmidt, C. E. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.027 · Cited by 134 · see citing works
Tailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineering
Chen, H., Huang, X., Zhang, M., Damanik, F., Baker, M. B., Leferink, A., Yuan, H., Truckenmüller, R. K., van Blitterswijk, C., & Moroni, L. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.07.003 · Cited by 134 · see citing works
Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke
Ghuman, H., Mauney, C., Donnelly, J., Massensini, A. R., Badylak, S. F., & Modo, M. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.020 · Cited by 133 · see citing works
Combination of Hyaluronic Acid Hydrogel Scaffold and PLGA Microspheres for Supporting Survival of Neural Stem Cells
Wang, Y., Wei, Y. T., Zu, Z. H., Ju, R., Guo, M. Y., Wang, X., Xu, Q. Y., & Cui, F. Z. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0452-3 · Cited by 132 · see citing works
Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
Carlson, A. L., Bennett, N. K., Francis, N. L., Halikere, A., Clarke, S. G., Moore, J. C., Hart, R. P., Paradiso, K. G., Wernig, M., Kohn, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10862 · Cited by 127 · see citing works
Architecture and migration of an epithelium on a cylindrical wire
Yevick, H. G., Duclos, G., Bonnet, I., & Silberzan, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418857112 · Cited by 126 · see citing works
Engineering immunomodulatory biomaterials for type 1 diabetes
Stabler, C. L., Li, Y., Stewart, J. M., & Keselowsky, B. G. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0112-5 · Cited by 126 · see citing works
Poly(vinylidene fluoride) and copolymers as porous membranes for tissue engineering applications
Nunes‐Pereira, J., Ribeiro, S., Ribeiro, C., Gombek, C. J., Gama, M., Gomes, A. C., Patterson, D. A., & Lanceros-Méndez, S. (2015) · Polymer Testing · doi:10.1016/j.polymertesting.2015.05.001 · Cited by 126 · see citing works
Compressive mechanical properties and biodegradability of porous poly(caprolactone)/chitosan scaffolds
Wan, Y., Wu, H., Cao, X., & Dalai, S. (2008) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2008.08.001 · Cited by 124 · see citing works
Hydrogels for brain repair after stroke: an emerging treatment option
Nih, L. R., Carmichael, S. T., & Segura, T. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.04.021 · Cited by 123 · see citing works
Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds
Hafeman, A. E., Zienkiewicz, K. J., Zachman, A. L., Sung, H., Nanney, L. B., Davidson, J. M., & Guelcher, S. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.108 · Cited by 120 · see citing works
Hyaluronic acid hydrogel as Nogo-66 receptor antibody delivery system for the repairing of injured rat brain: in vitro
Tian, W., Zhang, C. L., Hou, S., Yu, X., Cui, F. Z., Xu, Q., Sheng, S. L., Cui, H. Z., & Li, H. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.025 · Cited by 119 · see citing works
Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons
Adil, M. M., Vazin, T., Ananthanarayanan, B., Rodrigues, G., Rao, A. T., Kulkarni, R. U., Miller, E. W., Kumar, S., & Schaffer, D. V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.008 · Cited by 119 · see citing works
Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain
Cooke, M. J., Wang, Y., Morshead, C. M., & Shoichet, M. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.032 · Cited by 118 · see citing works
Mechanical Enhancement of Bioinspired Polydopamine Nanocoatings
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Self-citation
Histological evaluation of osteogenesis of 3D-printed poly-lactic-co-glycolic acid (PLGA) scaffolds in a rabbit model
Ge, Z., Tian, X., Heng, B. C., Fan, V., Yeo, J. F., & Cao, T. (2009) · Biomedical Materials · doi:10.1088/1748-6041/4/2/021001 · Cited by 117 · see citing works
Biomaterials for Brain Tissue Engineering
Pettikiriarachchi, J. T. S., Parish, C. L., Shoichet, M. S., Forsythe, J. S., & Nisbet, D. R. (2010) · Australian Journal of Chemistry · doi:10.1071/ch10159 · Cited by 115 · see citing works
Influencing chondrogenic differentiation of human mesenchymal stromal cells in scaffolds displaying a structural gradient in pore size
Luca, A. D., Szlązak, K., Lorenzo‐Moldero, I., Ghebes, C. A., Lepedda, A. J., Święszkowski, W., van Blitterswijk, C., & Moroni, L. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.03.014 · Cited by 114 · see citing works
The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis
Austin, J. W., Kang, C. E., Baumann, M. D., DiDiodato, L., Satkunendrarajah, K., Wilson, J. R., Stanisz, G. J., Shoichet, M. S., & Fehlings, M. G. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.022 · Cited by 112 · see citing works
Size dependent mechanical properties of electrospun polymer fibers from a composite structure
Stachewicz, U., Bailey, R. J., Wang, W., & Barber, A. H. (2012) · Polymer · doi:10.1016/j.polymer.2012.08.064 · Cited by 112 · see citing works
Competent processing techniques for scaffolds in tissue engineering
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Applying macromolecular crowding to 3D bioprinting: fabrication of 3D hierarchical porous collagen-based hydrogel constructs
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Effect of Fiber Diameter on the Spreading, Proliferation and Differentiation of Chondrocytes on Electrospun Chitosan Matrices
Noriega, S. E., Hasanova, G., Schneider, M., Larsen, G. F., & Subramanian, A. (2011) · Cells Tissues Organs · doi:10.1159/000325144 · Cited by 110 · see citing works

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Optimizing scaffold pore size for tissue engineering: insights across various tissue types
Mukasheva, F., Adilova, L., Dyussenbinov, A., Yernaimanova, B., Аbilev, М., & Akilbekova, D. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1444986 · Cited by 492 · see citing works
Interplay between Biomaterials and the Immune System: Perspective on Challenges and Opportunities in Regenerative Medicine
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Drug Delivery Systems in Regenerative Medicine: An Updated Review
Mansour, A., Romani, M., Acharya, A. B., Rahman, B., Verron, É., & Badran, Z. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020695 · Cited by 134 · see citing works
Viscoelastic Biomaterials for Tissue Regeneration
Wu, D. T. S., Jeffreys, N. C., Diba, M., & Mooney, D. J. (2022) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2022.0040 · Cited by 121 · see citing works
Polycaprolactone Composites/Blends and Their Applications Especially in Water Treatment
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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
High-resolution 3D printing of xanthan gum/nanocellulose bio-inks
Baniasadi, H., Kimiaei, E., Polez, R. T., Ajdary, R., Rojas, O. J., Österberg, M., & Seppälä, J. V. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.183 · Cited by 98 · see citing works
Deep-learning-based inverse design of three-dimensional architected cellular materials with the target porosity and stiffness using voxelized Voronoi lattices
Zheng, X., Chen, T., Jiang, X., Naito, M., & Watanabe, I. (2022) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2022.2157682 · Cited by 94 · see citing works
Advances of naturally derived biomedical polymers in tissue engineering
Hu, T., Fang, J., Shen, Y., Li, M., Wang, B., Xu, Z., & Hu, W. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1469183 · Cited by 88 · see citing works
Recent Applications of Electrospun Nanofibrous Scaffold in Tissue Engineering
Owida, H. A., Al-Nabulsi, J., Alnaimat, F., Al-Ayyad, M. S., Turab, N. M., Sharah, A. A., & Shakur, M. (2022) · Applied Bionics and Biomechanics · doi:10.1155/2022/1953861 · Cited by 80 · see citing works
A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology
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Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials
Nitti, P., Narayanan, A., Pellegrino, R., Villani, S., Madaghiele, M., & Demitri, C. (2023) · Bioengineering · doi:10.3390/bioengineering10101122 · Cited by 76 · see citing works
3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review
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Cellular Interaction of Human Skin Cells towards Natural Bioink via 3D-Bioprinting Technologies for Chronic Wound: A Comprehensive Review
Masri, S., Mazlan, Z., Zulkiflee, I., Salleh, A., Fadilah, N. I. M., Maarof, M., Wen, A. P. Y., Duman, F., Tabata, Y., Aziz, I. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010476 · Cited by 63 · see citing works
First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting
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Clinical challenges in bone tissue engineering - A narrative review
Hoveidaei, A. H., Sadat‐Shojai, M., Nabavizadeh, S. S., Niakan, R., Shirinezhad, A., Mosalamiaghili, S., & Tabaie, S. A. (2024) · Bone · doi:10.1016/j.bone.2024.117363 · Cited by 62 · see citing works
Polymeric Scaffolds Used in Dental Pulp Regeneration by Tissue Engineering Approach
Sugiaman, V. K., Jeffrey, J., Naliani, S., Pranata, N., Djuanda, R., & Saputri, R. I. (2023) · Polymers · doi:10.3390/polym15051082 · Cited by 58 · see citing works
Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure
Rajaram, K., Jakus, M. A., Chen, H., Jain, B., Kennedy, D. G., Caso, E. A., Mishra, N., Sharma, N., Uzunoğlu, B. E., Han, W. B., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado7538 · Cited by 58 · see citing works
3D Printing of Cellulase-Laden Cellulose Nanofiber/Chitosan Hydrogel Composites: Towards Tissue Engineering Functional Biomaterials with Enzyme-Mediated Biodegradation
Tamo, A. K., Tran, T. A., Doench, I., Jahangir, S., Lall, A., David, L., Peniche-Covas, C., Walther, A., & Osorio‐Madrazo, A. (2022) · Materials · doi:10.3390/ma15176039 · Cited by 57 · see citing works
Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives
Villanueva‐Flores, F., Garcia-Atutxa, I., Santos, A., & Armendáriz‐Borunda, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061750 · Cited by 57 · see citing works
A comprehensive review on natural macromolecular biopolymers for biomedical applications: Recent advancements, current challenges, and future outlooks
Manivannan, R., Sharma, N., Kumar, V., Iyyappan, J., Vimal, S., & Umesh, M. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100536 · Cited by 57 · see citing works
Sustainable biofabrication: from bioprinting to AI-driven predictive methods
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Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies
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Designing an Innovative Electrospinning Strategy to Generate PHBV Nanofiber Scaffolds with a Radially Oriented Fibrous Pattern
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Conducting polymer scaffolds: a new frontier in bioelectronics and bioengineering
Nasser, R. A., Arya, S. S., Alshehhi, K. H., Teo, J. C. M., & Pitsalidis, C. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.11.017 · Cited by 52 · see citing works
Electrically conductive coatings in tissue engineering
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Additive Manufacturing of Polymer/Bioactive Glass Scaffolds for Regenerative Medicine: A Review
Martelli, A., Bellucci, D., & Cannillo, V. (2023) · Polymers · doi:10.3390/polym15112473 · Cited by 49 · see citing works
LCST/UCST behavior of polysaccharides for hydrogel fabrication
Moon, S. H., Park, S. J., Lee, Y. W., & Yang, Y. J. (2024) · RSC Advances · doi:10.1039/d4ra06240j · Cited by 48 · see citing works
Vascularized 3D Human Skin Models in the Forefront of Dermatological Research
Rimal, R., Muduli, S., Desai, P., Marquez, A. B., Möller, M., Platzman, I., Spatz, J., & Singh, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303351 · Cited by 46 · see citing works
Gelatin-based scaffolds: An intuitive support structure for regenerative therapy
Rashid, A. B., Showva, N.-N., & Hoque, M. E. (2023) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2023.100452 · Cited by 44 · see citing works
Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques
Norouzi, S., Shemshaki, N. S., Norouzi, E., Latifi, M., Azimi, B., Danti, S., Qiao, X., Miao, Y., Yang, S., Gorji, M., et al. (2024) · Materials Today Chemistry · doi:10.1016/j.mtchem.2024.102016 · Cited by 42 · see citing works
Biomaterials-based strategy for dental-oral tissue regeneration: current clinical application, laboratory development, and future direction
Li, L., Xu, J., Ye, C., Zhou, Y., Yan, F., Chen, Z., & Xiao, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123714 · Cited by 42 · see citing works
Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 41 · see citing works
Cryopreservation of Tissue-Engineered Scaffold-Based Constructs: from Concept to Reality
Arutyunyan, I. V., Elchaninov, A. V., Sukhikh, G. T., & Fatkhudinov, T. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10299-4 · Cited by 34 · see citing works
Bioengineering of fibroblast‐conditioned polycaprolactone/gelatin electrospun scaffold for skin tissue engineering
Yazdanpanah, A., Madjd, Z., Pezeshki‐Modaress, M., Khosrowpour, Z., Farshi, P., Eini, L., Kiani, J., Seifi, M., Kundu, S. C., Ghods, R., et al. (2022) · Artificial Organs · doi:10.1111/aor.14169 · Cited by 33 · see citing works
Investigation of biodegradability and cellular activity of PCL/PLA and PCL/PLLA electrospun webs for tissue engineering applications
Öztemur, J., Özdemir, S., Tezcan-Unlu, H., Çeçener, G., Sezgin, H., & Yalçın-Eniş, İ. (2023) · Biopolymers · doi:10.1002/bip.23564 · Cited by 32 · see citing works
Effect of Sterilization Methods on Electrospun Scaffolds Produced from Blend of Polyurethane with Gelatin
Chernonosova, V. S., Kuzmin, I. E., Shundrina, I. K., Korobeynikov, M. V., Golyshev, V. M., Chelobanov, B. P., & Laktionov, P. P. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14020070 · Cited by 31 · see citing works
3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration
Codrea, C. I., Baykara, D., Mitran, R., Koyuncu, A. C. Ç., Gündüz, O., & Ficai, A. (2024) · Polymers · doi:10.3390/polym16131932 · Cited by 31 · see citing works
A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases
Wong, P. Y., Soo, S., Wong, E. S.-C., Praveen, P., Clode, P. L., Baker, M. V., & Matsubara, V. H. (2023) · International Dental Journal · doi:10.1016/j.identj.2023.01.002 · Cited by 30 · see citing works
Chitosan/hydroxyapatite hydrogels for localized drug delivery and tissue engineering: A review
Khodaverdi, K., Naghib, S. M., Mozafari, M., & Rahmanian, M. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100640 · Cited by 27 · see citing works
Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration
Kumar, P., Sharma, J., Kumar, R., Najser, J., Frantík, J., Manuja, A., Sunnam, N., & Praveenkumar, S. (2025) · Biomaterials Science · doi:10.1039/d4bm01606h · Cited by 25 · see citing works
Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regeneration
Cabral, ‪. S. D., de Melo‐Diogo, D., Ferreira, P. C. N., Moreira, A. F., & Correia, I. J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129210 · Cited by 25 · see citing works
Biomaterials for cardiovascular diseases
Huang, Y., & Ding, Z. (2024) · Biomedical Technology · doi:10.1016/j.bmt.2024.05.001 · Cited by 25 · see citing works
3D Engineered scaffolds of conjugated polymers/metal organic frameworks for biomedical applications
Sharifabad, A. H., Ghanbari, R., Saeb, M. R., Zare‬, E. N., Rossi, F., Salami‐Kalajahi, M., & Makvandi, P. (2025) · International Materials Reviews · doi:10.1177/09506608241299174 · Cited by 24 · see citing works
A Recent Insight into Research Pertaining to Collagen-Based Hydrogels as Dressings for Chronic Skin Wounds
Negrescu, A. M., & Cîmpean, A. (2025) · Gels · doi:10.3390/gels11070527 · Cited by 24 · see citing works
The role of three-dimensional scaffolds based on polyglycerol sebacate/ polycaprolactone/ gelatin in the presence of Nanohydroxyapatite in promoting chondrogenic differentiation of human adipose-derived mesenchymal stem cells
Talouki, P. Y., Tackallou, S. H., Shojaei, S., Benisi, S. Z., & Goodarzi, V. (2023) · Biological Procedures Online · doi:10.1186/s12575-023-00197-z · Cited by 23 · see citing works
Random cellulose acetate nanofibers: a breakthrough for cultivated meat production
dos Santos, A. E. A., Guadalupe, J. L., Albergaria, J. D. S., Almeida, I. A., Moreira, A. M. S., Copola, A. G. L., de Araújo, I. P., de Paula, A. M., Neves, B. R. A., Santos, J. P. F., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1297926 · Cited by 23 · see citing works
Bioengineering lungs: An overview of current methods, requirements, and challenges for constructing scaffolds
Shakir, S., Hackett, T., & Mostaço-Guidolin, L. B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1011800 · Cited by 22 · see citing works
Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications
Park, D., Lee, S. J., Choi, D. K., & Park, J.-W. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051522 · Cited by 22 · see citing works
The potential of graphene coatings as neural interfaces
Lopes, V., Moreira, G., Bramini, M., & Capasso, A. (2024) · Nanoscale Horizons · doi:10.1039/d3nh00461a · Cited by 22 · see citing works
Keratin nanofibers in tissue engineering: bridging nature and innovation
Aadil, K. R., Bhange, K., Kumar, N., & Mishra, G. (2024) · Biotechnology for Sustainable Materials · doi:10.1186/s44316-024-00019-6 · Cited by 22 · see citing works
Biodegradable graphene nanocomposites as functional biomaterials: a review of their role in controlled drug delivery and tissue engineering
Mohiuddin, M., Rahman, M. M., Uddin, M. N., Hasan, R., & Rahman, I. M. M. (2025) · RSC Advances · doi:10.1039/d5ra06280b · Cited by 21 · see citing works
Future Frontiers in Bioinspired Implanted Biomaterials
Gu, Q., Yuan, R., Sun, D., & Wallace, G. G. (2025) · Advanced Materials · doi:10.1002/adma.202506323 · Cited by 20 · see citing works
New Polymeric Composites Based on Two-Dimensional Nanomaterials for Biomedical Applications
Pires, L. S., Magalhães, F. D., & Pinto, A. M. (2022) · Polymers · doi:10.3390/polym14071464 · Cited by 20 · see citing works
Nanofiber Scaffold-Based Tissue Engineering for the Treatment of Acute Liver Failure
Liu, X., Yao, X., Ouyang, Q., Oliveira, A. L., Li, Y., & Zhang, Y. (2024) · Advanced Fiber Materials · doi:10.1007/s42765-024-00395-8 · Cited by 20 · see citing works
Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics
Kumar, R., Mishra, N., Tran, T., Kumar, M., Vijayaraghavalu, S., & Gurusamy, N. (2024) · Cells · doi:10.3390/cells13100855 · Cited by 20 · see citing works
Harnessing native blueprints for designing bioinks to bioprint functional cardiac tissue
Akter, M. Z., Tufail, F., Ahmad, A., Oh, Y. W., Kim, J. M., Kim, S., Hasan, M. M., Li, L., Lee, D., Kim, Y. S., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111882 · Cited by 20 · see citing works
Smart biomaterials for cardiovascular, bone, and skin tissue engineering: mechanisms, applications, and future prospects
Mohammadzadeh, M., Farzin, A., Pazhouhnia, Z., Hoseinpour, M., & Beheshtizadeh, N. (2026) · Journal of Biological Engineering · doi:10.1186/s13036-025-00607-8 · Cited by 19 · see citing works
Fused filament fabrication of polycaprolactone bioscaffolds: Influence of fabrication parameters and thermal environment on geometric fidelity and mechanical properties
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Authors: Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K.
Affiliations: University of California, Berkeley (US)
Corresponding author: Komvopoulos, Kyriakos
ORCID: Malollari, Katerina G.
Komvopoulos, Kyriakos
Venue: Frontiers in Bioengineering and Biotechnology
Publisher: Frontiers Media SA
Published: 2021-06-14
Volume: 9
Pages: 617141-617141
ISSN: 2296-4185 (ISSN-L)
DOI: 10.3389/fbioe.2021.617141
PMC: PMC8236583
OpenAlex: W3171498185
Cited by: 397
References: 318
Citations by year: 2026: 103 · 2025: 124 · 2024: 89 · 2023: 49 · 2022: 30 · 2021: 2
FWCI: 3.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords: polymer scaffolds, tissue engineering, biodegradable biomaterials, scaffold design, biodegradation, cell behavior, scaffold architecture, mechanical properties, skin regeneration, brain tissue regeneration

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Design Challenges in Polymeric Scaffolds for Tissue Engineering

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