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PASADENA Hyperpolarization of Succinic Acid for MRI and NMR Spectroscopy
Open accessAbstract
We use the PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) method to achieve 13C polarization of approximately 20% in seconds in 1-13C-succinic-d2 acid. The high-field 13C multiplets are observed as a function of pH, and the line broadening of C1 is pronounced in the region of the pK values. The 2JCH, 3JCH, and 3JHH couplings needed for spin order transfer vary with pH and are best resolved at low pH leading to our use of pH approximately 3 for both the molecular addition of parahydrogen to 1-13C-fumaric acid-d2 and the subsequent transfer of spin order from the nascent protons to C1 of the succinic acid product. The methods described here may generalize to hyperpolarization of other carboxylic acids. The C1 spin-lattice relaxation time at neutral pH and 4.7 T is measured as 27 s in H2O and 56 s in D2O. Together with known rates of succinate uptake in kidneys, this allows an estimate of the prospects for the molecular spectroscopy of metabolism.
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Cited by
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Self-citationThe theory and practice of hyperpolarization in magnetic resonance using parahydrogen
Green, R. A., Adams, R. W., Duckett, S. B., Mewis, R. E., Williamson, D. C., & Green, G. G. R. (2012) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2012.03.001 · Cited by 381
Parahydrogen‐Based Hyperpolarization for Biomedicine
Hövener, J., Pravdivtsev, A. N., Kidd, B., Bowers, C. R., Glöggler, S., Kovtunov, K. V., Plaumann, M., Katz‐Brull, R., Buckenmaier, K., Jerschow, A., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201711842 · Cited by 346
Self-citationParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
Reineri, F., Boi, T., & Aime, S. (2015) · Nature Communications · doi:10.1038/ncomms6858 · Cited by 296
Metadata
- Authors
- Chekmenev, E. Y., Hövener, J., Norton, V. A., Harris, K., Batchelder, L. S., Bhattacharya, P., Ross, B. D., & Weitekamp, D. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-03-12
- Volume
- 130
- Issue
- 13
- Pages
- 4212-4213
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2018659844
- Cited by
- 184
- References
- 0
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Chekmenev, E. Y., Hövener, J., Norton, V. A., Harris, K., Batchelder, L. S., Bhattacharya, P., Ross, B. D., & Weitekamp, D. P. (2008). PASADENA Hyperpolarization of Succinic Acid for MRI and NMR Spectroscopy. Journal of the American Chemical Society. https://doi.org/10.1021/ja7101218
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