The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Parahydrogen‐Based Hyperpolarization for Biomedicine
Open accessAbstract
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH 2), which is inherently stable and long‐lived. When brought into contact with another molecule, this “spin order on demand” allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH 2‐based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.
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Wang, J., Sánchez-Roselló, M., Aceña, J. L., del Pozo, C., Sorochinsky, A. E., Fustero, S., Soloshonok, V. A., & Liu, H. (2014) · Chemical Reviews · doi:10.1021/cr4002879 · Cited by 4,847
Non-adiabatic crossing of energy levels
Zener, C. (1932) · Proceedings of the Royal Society of London Series A Containing Papers of a Mathematical and Physical Character · doi:10.1098/rspa.1932.0165 · Cited by 4,572
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
Ardenkjær-Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., & Golman, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733835100 · Cited by 2,861
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
Molecular imaging of cancer with positron emission tomography
Gambhir, S. S. (2002) · Nature Reviews Cancer · doi:10.1038/nrc882 · Cited by 1,656
Spin-exchange optical pumping of noble-gas nuclei
Walker, T. G., & Happer, W. (1997) · Reviews of Modern Physics · doi:10.1103/revmodphys.69.629 · Cited by 1,444
Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- 13 C]Pyruvate
Nelson, S. J., Kurhanewicz, J., Vigneron, D. B., Larson, P. E. Z., Harzstark, A. L., Ferrone, M., van Criekinge, M., Chang, J. W., Bok, R., Park, I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006070 · Cited by 1,286
(1996) · PubMed · Cited by 1,188
Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer
Adams, R. W., Aguilar, J. A., Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., Green, G. G. R., Khazal, I. G., López-Serrano, J., & Williamson, D. C. (2009) · Science · doi:10.1126/science.1168877 · Cited by 1,031
Parahydrogen and synthesis allow dramatically enhanced nuclear alignment
Bowers, C. R., & Weitekamp, D. P. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00252a049 · Cited by 1,028
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Metadata
- Authors
- Hövener, J., Pravdivtsev, A. N., Kidd, B., Bowers, C. R., Glöggler, S., Kovtunov, K. V., Plaumann, M., Katz‐Brull, R., Buckenmaier, K., Jerschow, A., Reineri, F., Theis, T., Shchepin, R. V., Wagner, S., Bhattacharya, P., Zacharias, N. M., & Chekmenev, E. Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-08
- Volume
- 57
- Issue
- 35
- Pages
- 11140-11162
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2793497834
- Cited by
- 346
- References
- 134
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Hövener, J., Pravdivtsev, A. N., Kidd, B., Bowers, C. R., Glöggler, S., Kovtunov, K. V., Plaumann, M., Katz‐Brull, R., Buckenmaier, K., Jerschow, A., Reineri, F., Theis, T., Shchepin, R. V., Wagner, S., Bhattacharya, P., Zacharias, N. M., & Chekmenev, E. Y. (2018). Parahydrogen‐Based Hyperpolarization for Biomedicine. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201711842
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
