The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity
Abstract
We report a two-color, cell-based screen to identify specific receptor-binding compounds in a combinatorial library of peptoids displayed on beads. We apply this strategy to the isolation of vascular endothelial growth factor receptor 2 (VEGFR2)-binding peptoids. A dimeric derivative of one of these lead compounds is shown to be an antagonist of VEGFR2 activity both in vitro and in vivo. This methodology provides a potentially general route to synthetic molecules that bind integral membrane receptors with affinities and specificities similar to those of antibodies, but which are far smaller and easier to make and manipulate.
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Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605
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G protein-coupled receptors: structure- and function-based drug discovery
Yang, D., Zhou, Q., Labroska, V., Qin, S., Darbalaei, S., Wu, Y., Yuliantie, E., Xie, L., Tao, H., Cheng, J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00435-w · Cited by 632
Modulators of Protein–Protein Interactions
Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497
Ten things you should know about protein kinases: IUPHAR R eview 14
Fabbro, D., Cowan‐Jacob, S. W., & Moebitz, H. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13096 · Cited by 347
Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Buckley, D. L., Gustafson, J. L., Van Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A., & Crews, C. M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206231 · Cited by 302
Peptoids and Polypeptoids at the Frontier of Supra- and Macromolecular Engineering
Gangloff, N., Ulbricht, J., Lorson, T., Schlaad, H., & Luxenhofer, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00201 · Cited by 265
Metadata
- Authors
- Udugamasooriya, D. G., Dineen, S. P., Brekken, R. A., & Kodadek, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-01
- Volume
- 130
- Issue
- 17
- Pages
- 5744-5752
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1964302063
- Cited by
- 222
- References
- 2
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Udugamasooriya, D. G., Dineen, S. P., Brekken, R. A., & Kodadek, T. (2008). A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity. Journal of the American Chemical Society. https://doi.org/10.1021/ja711193x
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