The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An Enzyme-Based E-DNA Sensor for Sequence-Specific Detection of Femtomolar DNA Targets
Abstract
In this work, we report an enzyme-based E-DNA sensor for the sequence-specific detection of nucleic acids. This DNA sensor employs a "stem-loop" DNA probe dually labeled with biotin and digoxigenin (DIG). The probe is immobilized at an avidin-modified electrode surface via the biotin-avidin bridge, and the DIG serves as an affinity tag for the enzyme binding. In the initial state of the sensor, the probe adopts the stem-loop structure, which shields DIG from being approached by a bulky horseradish peroxidase-linked-anti-DIG antibody (anti-DIG-HRP) due to the steric effect. After hybridization, the probe undergoes a significant conformational change, forcing DIG away from the electrode. As a result, the DIG label becomes accessible by the anti-DIG-HRP, and the target hybridization event can be sensitively transduced via the enzymatically amplified electrochemical current signal. By using this new strategy, we demonstrate that the prototype E-DNA sensor has been able to detect as low as femtomolar DNA targets with excellent differentiation ability for even single mismatches.
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Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Zhang, J., Song, S., Zhang, L., Wang, L., Wu, H., Pan, D., & Fan, C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061521a · Cited by 424
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Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Functional DNA Nanostructures for Theranostic Applications
Pei, H., Zuo, X., Zhu, D., Huang, Q., & Fan, C. (2014) · Accounts of Chemical Research · doi:10.1021/ar400195t · Cited by 409
Self-citationWen, Y., Pei, H., Wan, Y., Su, Y., Huang, Q., Song, S., & Fan, C. (2011) · Analytical Chemistry · doi:10.1021/ac201491p · Cited by 265
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Metadata
- Authors
- Liu, G., Wan, Y., Gau, V., Zhang, J., Wang, L., Song, S., & Fan, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-01
- Volume
- 130
- Issue
- 21
- Pages
- 6820-6825
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2095171944
- Cited by
- 418
- References
- 2
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, G., Wan, Y., Gau, V., Zhang, J., Wang, L., Song, S., & Fan, C. (2008). An Enzyme-Based E-DNA Sensor for Sequence-Specific Detection of Femtomolar DNA Targets. Journal of the American Chemical Society. https://doi.org/10.1021/ja800554t
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