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Engineering Target-Responsive Hydrogels Based on Aptamer−Target Interactions
Open accessAbstract
In this communication, we report a simple, but highly adaptable, method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. In this design, competitive binding of target to the aptamer causes the decrease of cross-linking density and, hence, dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was demonstrated using two different types of targets, small molecules and proteins. Our results indicated that this molecular engineering provides a highly selective and controllable release system whereby efficient release of therapeutic agents can occur at specific environments in which the target biomarker is found.
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Cited by
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Self-citationEl-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
Dave, N., Chan, M. Y., Huang, P.-J. J., Smith, B. D., & Liu, J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106098j · Cited by 461
Yan, B., Boyer, J.-C., Habault, D., Branda, N. R., & Zhao, Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308876j · Cited by 417
Metadata
- Authors
- Yang, H., Liu, H., Kang, H., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-29
- Volume
- 130
- Issue
- 20
- Pages
- 6320-6321
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2084064316
- Cited by
- 363
- References
- 0
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, H., Liu, H., Kang, H., & Tan, W. (2008). Engineering Target-Responsive Hydrogels Based on Aptamer−Target Interactions. Journal of the American Chemical Society. https://doi.org/10.1021/ja801339w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
