The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Platinum Supramolecular Square as an Effective G-Quadruplex Binder and Telomerase Inhibitor
Abstract
In this contribution, we report that a self-assembled platinum molecular square [Pt(en)(4,4'-dipyridyl)]4 can act as an efficient G-quadruplex binder and telomerase inhibitor. Molecular modeling studies show that the square arrangement of the four bipyridyl ligands, the highly electropositive nature of the overall complex, as well as hydrogen bonding interactions between the ethylenediamine ligands and phosphates of the DNA backbone all contribute to the observed strong binding affinity to the G-quadruplex. Through thermal denaturation studies with duplex and quadruplex FRET probes and enzymatic assays, we demonstrate that this platinum square strongly binds to G-quadruplexes and can act as an inhibitor of telomerase. This study thus shows the potential of supramolecular self-assembly to readily generate scaffolds of unique geometries for effective targeting of G-quadruplexes and for the ultimate development of selective antitumor therapies.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Cited by
Seeman, N. C. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-102244 · Cited by 992
Rodriguez, R., Müller, S., Yeoman, J. A., Trentesaux, C., Riou, J.-F., & Balasubramanian, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja805615w · Cited by 517
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Ma, D.-L., Che, C.-M., & Yan, S.-C. (2009) · Journal of the American Chemical Society · doi:10.1021/ja806045x · Cited by 289
G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs
Cao, Q., Li, Y., Freisinger, E., Qin, P. Z., Sigel, R. K. O., & Mao, Z.-W. (2017) · Inorganic Chemistry Frontiers · doi:10.1039/c6qi00300a · Cited by 265
Metadata
- Authors
- Kieltyka, R., Englebienne, P., Fakhoury, J., Autexier, C., Moitessier, N., & Sleiman, H. F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-11
- Volume
- 130
- Issue
- 31
- Pages
- 10040-10041
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2054402484
- Cited by
- 206
- References
- 1
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
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