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Aptamer-Facilitated Biomarker Discovery (AptaBiD)
Abstract
Here we introduce a technology for biomarker discovery in which (i) DNA aptamers to biomarkers differentially expressed on the surfaces of cells being in different states are selected; (ii) aptamers are used to isolate biomarkers from the cells; and (iii) the isolated biomarkers are identified by means of mass spectrometry. The technology is termed aptamer-facilitated biomarker discovery (AptaBiD). AptaBiD was used to discover surface biomarkers that distinguish live mature and immature dendritic cells. We selected in vitro two DNA aptamer pools that specifically bind to mature and immature dendritic cells with a difference in strength of approximately 100 times. The aptamer pools were proven to be highly efficient in flow- and magnetic-bead-assisted separation of mature cells from immature cells. The two aptamer pools were then used to isolate biomarkers from the cells. The subsequent mass spectrometry analysis of the isolated proteins revealed unknown biomarkers of immature and mature dendritic cells.
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Cites
Protein biomarker discovery and validation: the long and uncertain path to clinical utility
Rifai, N., Gillette, M. A., & Carr, S. A. (2006) · Nature Biotechnology · doi:10.1038/nbt1235 · Cited by 1,867
Cited by
Aptamers from Cell-Based Selection for Bioanalytical Applications
Tan, W., Donovan, M. J., & Jiang, J. (2013) · Chemical Reviews · doi:10.1021/cr300468w · Cited by 649
The Chemical Biology of Aptamers
Mayer, G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200804643 · Cited by 592
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons
Ni, X., Castanares, M., Mukherjee, A., & Lupold, S. E. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797189600 · Cited by 349
In vivo selection of tumor-targeting RNA motifs
Mi, J., Liu, Y., Rabbani, Z. N., Yang, Z., Urban, J. H., Sullenger, B. A., & Clary, B. M. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.277 · Cited by 269
Metadata
- Authors
- Berezovski, M. V., Lechmann, M., Musheev, M. U., Mak, T. W., & Krylov, S. N.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-18
- Volume
- 130
- Issue
- 28
- Pages
- 9137-9143
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2075826965
- Cited by
- 198
- References
- 1
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berezovski, M. V., Lechmann, M., Musheev, M. U., Mak, T. W., & Krylov, S. N. (2008). Aptamer-Facilitated Biomarker Discovery (AptaBiD). Journal of the American Chemical Society. https://doi.org/10.1021/ja801951p
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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