The DOI matches its Crossref record; 197 of the 197 references it cites were found in a registry or an index.
The Chemical Biology of Aptamers
Abstract
Taking a strand: Aptamers are small single‐stranded oligonucleotides that fold into a well‐defined 3D structure and interact with high affinity and specificity with their target molecules, thereby inhibiting their biological functions. Aptamers can be synthesized by either chemical and/or enzymatic procedures and can thus be considered as both chemical and biological substances. The current status and new developments in this area are described.magnified image Aptamers are small single‐stranded nucleic acids that fold into a well‐defined three‐dimensional structure. They show a high affinity and specificity for their target molecules and inhibit their biological functions. Aptamers belong to the nucleic acids family and can be synthesized by chemical or enzymatic procedures, or a combination of the two. They can, therefore, be considered as both chemical and biological substances. This Review summarizes the most convenient approaches to their preparation and new developments in the field of aptamers. The application of aptamers in chemical biology is also discussed.
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1 retracted
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Cited by
Analysis of aptamer discovery and technology
Dunn, M. R., Jimenez, R. M., & Chaput, J. C. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0076 · Cited by 938
Small-Molecule Binding Aptamers: Selection Strategies, Characterization, and Applications
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Semisynthetic DNA–Protein Conjugates for Biosensing and Nanofabrication
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Nucleic acid aptamers in cancer research, diagnosis and therapy
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Metadata
- Authors
- Mayer, G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-03-24
- Volume
- 48
- Issue
- 15
- Pages
- 2672-2689
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2072461007
- Cited by
- 592
- References
- 197
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- closed
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