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Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes
Open accessAbstract
A strategy for targeting protein kinases with large ATP-binding sites by using bulky and rigid octahedral ruthenium complexes as structural scaffolds is presented. A highly potent and selective GSK3 and Pim1 half-sandwich complex NP309 was successfully converted into a PAK1 inhibitor by making use of the large octahedral compounds Lambda-FL172 and Lambda-FL411 in which the cyclopentadienyl moiety of NP309 is replaced by a chloride and sterically demanding diimine ligands. A 1.65 A cocrystal structure of PAK1 with Lambda-FL172 reveals how the large coordination sphere of the ruthenium complex matches the size of the active site and serves as a yardstick to discriminate between otherwise closely related binding sites.
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Cited by
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Radu, M., Semenova, G., Kosoff, R., & Chernoff, J. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3645 · Cited by 503
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Romero-Canelón, I., & Sadler, P. J. (2013) · Inorganic Chemistry · doi:10.1021/ic400835n · Cited by 396
Scott, L. E., & Orvig, C. (2009) · Chemical Reviews · doi:10.1021/cr9000176 · Cited by 332
Metadata
- Authors
- Maksimoska, J., Feng, L., Harms, K., Yi, C., Kissil, J., Marmorstein, R., & Meggers, E.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-31
- Volume
- 130
- Issue
- 47
- Pages
- 15764-15765
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2018431023
- Cited by
- 200
- References
- 0
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes. https://app.cochat.ai/papers/10.1021/ja805555a
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- Maksimoska, J., Feng, L., Harms, K., Yi, C., Kissil, J., Marmorstein, R., & Meggers, E. (2008). Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes. Journal of the American Chemical Society. https://doi.org/10.1021/ja805555a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
