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Cited by 335Heavy Metal Exposure and ToxicityMetal complexes synthesis and propertiesTrace Elements in Health

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

Scott, Lauren E., Orvig, Chris·2009·Chemical Reviews
DOI 10.1021/cr9000176
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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMedicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in DiseaseLauren E. Scott and Chris Orvig*View Author Information Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, Canada* To whom correspondence should be addressed. Mailing address: University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. Phone: (604) 822-4449. Fax: (604) 822-2847. E-mail: [email protected]Cite this: Chem. Rev. 2009, 109, 10, 4885–4910Publication Date (Web):July 28, 2009Publication History Received15 January 2009Published online28 July 2009Published inissue 14 October 2009https://pubs.acs.org/doi/10.1021/cr9000176https://doi.org/10.1021/cr9000176review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views6754Altmetric-Citations275LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a…

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324 of 324 references verified0 citation errors · 0 not checkable

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  • L1 and L2 satisfy Lipinski's rules for BBB penetration and calculated logBB values, suggesting they should be capable of crossing the BBB.

    “Considering the restrictive Lipinski’s rules for BBB penetration (MW ≤ 450, clogP ≤5, hydrogen bond donors ≤ 5, hydrogen bond acceptors ≤ 10, polar surface area ≤ 90 Å2) and the calculated logBB values (Table S2), both L1 and L2 satisfy these requirements, suggesting that these compounds should be capable of crossing the BBB.”

    From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [31]

  • These metal ions have been shown to promote Aβ40 aggregation.

    “Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”

    From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [31]

  • These metal ions lead to formation of reactive oxygen species (ROS) and oxidative stress.

    “as well as lead to formation of reactive oxygen species (ROS) and oxidative stress.3,26–31,33–36”

    From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [31]

  • Use of non-specific chelators (i.e., CQ) that do not interact selectively with the Aβ-metal species exhibit adverse side effects that will likely limit their long term clinical use.

    “However, use of non-specific chelators (i.e., CQ) that do not interact selectively with the Aβ–metal species exhibit adverse side effects that will likely limit their long term clinical use.3,28,29,31,44,46–48”

    From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [31]

  • Two approaches have been pursued in BFC design: direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compound, and linking the metal-chelating and Aβ-binding molecular fragments.

    “In this context, two approaches have been pursued in BFC design. 31,49–58 One strategy is based on the direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compoud (Scheme 1, approach A), and the other involves linking the metal-chelating and Aβ-binding molecular fragments (Scheme 1, approach B).”

    From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [31]

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Authors
Scott, L. E., & Orvig, C.
Affiliations
University of British Columbia (CA)
Corresponding author
Orvig, Chris
ORCID
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2009-07-28
Volume
109
Issue
10
Pages
4885-4910
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/cr9000176
OpenAlex
W2058402591
Cited by
332
References
327
Citations by year
2026: 6 · 2025: 10 · 2024: 15 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 14 · 2018: 21 · 2017: 16 · 2016: 13 · 2015: 25 · 2014: 18 · 2013: 41 · 2012: 44
FWCI
4.32
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
metal ion removal, metal-based drugs, iron
MeSH terms
Animals, Chemistry, Pharmaceutical, Disease, Humans, Metals, Therapeutics, Chemistry, Inorganic

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