The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multiplexed Multicolor Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes
Open accessAbstract
We show that single walled carbon nanotubes (SWNTs) with different isotope compositions exhibit distinct Raman G-band peaks and can be used for multiplexed multicolor Raman imaging of biological systems. Cancer cells with specific receptors are selectively labeled with three differently "colored" SWNTs conjugated with various targeting ligands including Herceptin (anti-Her2), Erbitux (anti-Her1), and RGD peptide, allowing for multicolor Raman imaging of cells in a multiplexed manner. SWNT Raman signals are highly robust against photobleaching, allowing long-term imaging and tracking. With narrow peak features, SWNT Raman signals are easily differentiated from the autofluorescence background. The SWNT Raman excitation and scattering photons are in the near-infrared region, which is the most transparent optical window for biological systems in vitro and in vivo. Thus, SWNTs are novel Raman tags promising for multiplexed biological detection and imaging.
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Cites
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Cited by
Zavaleta, C. L., Smith, B. R., Walton, I., Doering, W., Davis, G., Shojaei, B., Natan, M. J., & Gambhir, S. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813327106 · Cited by 714
Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals
Wu, S., Han, G., Milliron, D. J., Aloni, S., Altoe, V., Talapin, D. V., Cohen, B. E., & Schuck, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904792106 · Cited by 710
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
Liu, X., Tao, H., Yang, K., Zhang, S., Lee, S.-T., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.096 · Cited by 417
Self-citationStimulated Raman scattering microscopy: an emerging tool for drug discovery
Tipping, W. J., Lee, M., Serrels, A., Brunton, V. G., & Hulme, A. N. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00693g · Cited by 266
Metadata
- Authors
- Liu, Z., Li, X., Tabakman, S. M., Jiang, K., Fan, S., & Dai, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-09-20
- Volume
- 130
- Issue
- 41
- Pages
- 13540-13541
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2076400978
- Cited by
- 261
- References
- 1
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, Z., Li, X., Tabakman, S. M., Jiang, K., Fan, S., & Dai, H. (2008). Multiplexed Multicolor Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes. Journal of the American Chemical Society. https://doi.org/10.1021/ja806242t
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