The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Surface-Enhanced Raman Nanoparticle Beacons Based on Bioconjugated Gold Nanocrystals and Long Range Plasmonic Coupling
Open accessAbstract
We have developed a new class of surface-enhanced Raman scattering beacons (SERS beacons) that can be turned on and off by long-range plasmonic coupling, induced by biomolecular recognition and binding events. The beacons are based on colloidal gold nanocrystals in two sizes (40 and 60 nm) and are prepared by spectral encoding with a Raman reporter molecule, functionalized with thiolated DNA probes, and stabilized and protected by low molecular weight poly(ethylene glycol)s (PEGs). The results show the SERS signal intensities increase by 40-200-fold when the nanoparticle beacons are activated by plasmonic coupling, much higher than the bright-to-dark intensity ratios reported for traditional molecular beacons. Multivalent gold nanoparticles also have exquisite specificity and are able to recognize single-base mismatches or mutations. This class of SERS nanoparticle beacons has novel mechanisms for molecular detection and signal amplification, and its long-range coupling nature raises new opportunities in developing plasmonic probes to detect proteins, cells, and intact viruses.
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Citations
Cites
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Self-citation
Cited by
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873
Self-citationGuerrini, L., & Graham, D. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35118h · Cited by 441
Multiplex in vitro detection using SERS
Laing, S., Gracie, K., & Faulds, K. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00644a · Cited by 361
Plasmonic colorimetric and SERS sensors for environmental analysis
Wei, H., Hossein Abtahi, S. M., & Vikesland, P. J. (2015) · Environmental Science: Nano · doi:10.1039/c4en00211c · Cited by 285
Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection
He, Y., Su, S., Xu, T., Zhong, Y., Zapien, J. A., Li, J., Fan, C., & Lee, S.-T. (2011) · Nano Today · doi:10.1016/j.nantod.2011.02.004 · Cited by 284
Metadata
- Authors
- Qian, X., Zhou, X., & Nie, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-21
- Volume
- 130
- Issue
- 45
- Pages
- 14934-14935
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2030583923
- Cited by
- 235
- References
- 1
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Qian, X., Zhou, X., & Nie, S. (2008). Surface-Enhanced Raman Nanoparticle Beacons Based on Bioconjugated Gold Nanocrystals and Long Range Plasmonic Coupling. Journal of the American Chemical Society. https://doi.org/10.1021/ja8062502
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