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Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates
Open accessAbstract
We report the synthesis and characterization of polyvalent RNA-gold nanoparticle conjugates (RNA-Au NPs), nanoparticles that are densely functionalized with synthetic RNA oligonucleotides and designed to function in the RNAi pathway. The particles were rationally designed and synthesized to be free of degrading enzymes, have a high surface loading of siRNA duplexes, and contain an auxiliary passivating agent for increased stability in biological media. The resultant conjugates have a half-life six times longer than that of free dsRNA, readily enter cells without the use of transfection agents, and demonstrate a high gene knockdown capability in a cell model.
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Citations
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. J., Patel, P. C., Cutler, J. I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006839 · Cited by 592
Self-citationA Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
A Review of Clinical Translation of Inorganic Nanoparticles
Anselmo, A. C., & Mitragotri, S. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9780-2 · Cited by 509
Metadata
- Authors
- Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-01-26
- Volume
- 131
- Issue
- 6
- Pages
- 2072-2073
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2073658360
- Cited by
- 637
- References
- 0
- FWCI
- 20.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A. (2009). Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates. Journal of the American Chemical Society. https://doi.org/10.1021/ja808719p
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
