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Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography
Abstract
Nanoscale topography was constructed on a thermally responsive poly(N-isopropylacrylamide) (PNIPAAm) surface by grafting the polymer from silicon nanowire arrays via surface-initiated atom transfer radical polymerization. The as-prepared surface showed largely reduced platelet adhesion in vitro both below and above the lower critical solution temperature (LCST) of PNIPAAm ( approximately 32 degrees C), while a smooth PNIPAAm surface exhibited antiadhesion to platelets only below the LCST. Contact angle and adhesive force measurements on oil droplets (1,2-dichloroethane) in water demonstrated that the nanoscale topography kept a relatively high ratio of water content on the as-prepared surface and played a key role in largely reducing the adhesion of platelets; however, this effect did not exist on the smooth PNIPAAm surface. The results can be used to extend the applications of PNIPAAm in the fields of biomaterials and biomedicine under human physiological temperature and provide a new strategy for fabricating other blood-compatible materials.
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Cites
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces
Xu, L.-C., & Siedlecki, C. A. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.032 · Cited by 715
Cited by
Zoppe, J. O., Ataman, N. C., Mocny, P., Wang, J., Moraes, J., & Klok, H.-A. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00314 · Cited by 1,046
Superhydrophilic–superoleophobic coatings
Yang, J., Zhang, Z., Xu, X., Zhu, X., Men, X., & Zhou, X. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm15987b · Cited by 406
Three-dimensional nano-biointerface as a new platform for guiding cell fate
Liu, X., & Wang, S. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60419e · Cited by 275
Designing Bioinspired Anti‐Biofouling Surfaces based on a Superwettability Strategy
Zhang, P., Lin, L., Zang, D., Guo, X., & Liu, M. (2017) · Small · doi:10.1002/smll.201503334 · Cited by 266
Self-citationBiomimetic Smart Interface Materials for Biological Applications
Sun, T., & Qing, G. (2011) · Advanced Materials · doi:10.1002/adma.201004326 · Cited by 261
Metadata
- Authors
- Chen, L., Liu, M., Bai, H., Chen, P., Xia, F., Han, D., & Jiang, L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-07-09
- Volume
- 131
- Issue
- 30
- Pages
- 10467-10472
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1969478458
- Cited by
- 207
- References
- 2
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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