Cited by 2,607Cellular Mechanics and InteractionsTissue Engineering and Regenerative MedicineBone Tissue Engineering Materials

Exploring and Engineering the Cell Surface Interface

Stevens, Molly M., George, Julian H.·2005·Science

Abstract

Cells are inherently sensitive to local mesoscale, microscale, and nanoscale patterns of chemistry and topography. We review current approaches to control cell behavior through the nanoscale engineering of materials surfaces. Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.

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Registry

Crossref · 10.1126/science.1106587

Cites

62 of 62 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a three-dimensional collagen fibril matrix, a migrating breast carcinoma cell produces similar forces despite changes in the stiffness of the matrix.

    “They found that similar forces are generated even as the stiffness of the matrix is changed.”

    From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [105]

  • Steinwechs et al. were the first to measure the forces generated by a breast carcinoma cell as it migrated through a three-dimensional collagen fibril matrix.

    “Steinwechs et al. (105) quantified, for the first time, the forces resulting from a breast carcinoma cell that migrates within a 3D collagen fibril matrix.”

    From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [105]

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Authors
Stevens, M. M., & George, J. H.
Affiliations
Imperial College London (GB)
Corresponding author
Stevens, Molly M.
Venue
Science
Published
2005-11-18
Volume
310
Issue
5751
Pages
1135-1138
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1982769493
Cited by
2,607
References
64
Citations by year
2026: 30 · 2025: 57 · 2024: 57 · 2023: 90 · 2022: 91 · 2021: 117 · 2020: 132 · 2019: 126 · 2018: 165 · 2017: 166 · 2016: 185 · 2015: 145 · 2014: 202 · 2013: 177 · 2012: 177
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
Engineering and Physical Sciences Research Council (EP/C520742/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
nanoscale surface patterning, cell-material interactions, cell behavior control, surface topography, surface chemistry, biomedical implants, tissue regeneration, 3D scaffolds
MeSH terms
Animals, Biocompatible Materials, Cell Membrane, Cell Physiological Phenomena, Extracellular Matrix, Forecasting, Humans, Surface Properties, Tissue Engineering, Nanotechnology

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