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Cited by 184

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Stimuli-Responsive SERS Nanoparticles: Conformational Control of Plasmonic Coupling and Surface Raman Enhancement

Open access
Qian, Ximei, Li, Jun, Nie, Shuming·2009·Journal of the American Chemical Society

Abstract

Stimuli-responsive surface-enhanced Raman scattering (SERS) nanoparticles have been developed by using colloidal gold nanocrystals and a class of thiolated block copolymers consisting of a pH-responsive polymer segment, an amphiphilic polyethylene glycol segment, and a lipoic acid anchoring group. The results demonstrate that SERS signals can be switched on and off by molecular conformations in response to pH. An important finding is that neutralized polymethacrylic acid (PMAA) molecules are able to interact with amphiphilic polyethylene glycol (PEG) chains, leading to highly compact and intermingled copolymer structures on the surface of nanoparticles. This type of molecular conformation change provides a new strategy for controlling plasmonic coupling and electromagnetic Raman enhancement and raises the possibility of using SERS nanoparticle tags for biomolecular binding and enzymatic cleavage studies.

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Crossref · 10.1021/ja902226z

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Metadata

Authors
Qian, X., Li, J., & Nie, S.
Venue
Journal of the American Chemical Society
Published
2009-05-19
Volume
131
Issue
22
Pages
7540-7541
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2008667815
Cited by
184
References
1
FWCI
5.87
Type
journal article
Language
en
Open access
green

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