The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand
Abstract
We present a new class of polymeric ligands for quantum dot (QD) water solubilization to yield biocompatible and derivatizable QDs with compact size (∼10−12 nm diameter), high quantum yields (>50%), excellent stability across a large pH range (pH 5−10.5), and low nonspecific binding. To address the fundamental problem of thiol instability in traditional ligand exchange systems, the polymers here employ a stable multidentate imidazole binding motif to the QD surface. The polymers are synthesized via reversible addition−fragmentation chain transfer-mediated polymerization to produce molecular weight controlled monodisperse random copolymers from three types of monomers that feature imidazole groups for QD binding, polyethylene glycol (PEG) groups for water solubilization, and either primary amines or biotin groups for derivatization. The polymer architecture can be tuned by the monomer ratios to yield aqueous QDs with targeted surface functionalities. By incorporating amino-PEG monomers, we demonstrate covalent conjugation of a dye to form a highly efficient QD-dye energy transfer pair as well as covalent conjugation to streptavidin for high-affinity single molecule imaging of biotinylated receptors on live cells with minimal nonspecific binding. The small size and low serum binding of these polymer-coated QDs also allow us to demonstrate their utility for in vivo imaging of the tumor microenvironment in live mice.
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Cites
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Self-citationSemiconductor Nanocrystals as Fluorescent Biological Labels
Bruchez, M., Moronne, M., Gin, P., Weiss, S., & Alivisatos, A. P. (1998) · Science · doi:10.1126/science.281.5385.2013 · Cited by 8,613
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,790
Chiefari, J., Chong, Y. K. (., Ercole, F., Krstina, J., Jeffery, J., Le, T. P. T., Mayadunne, R. T. A., Meijs, G. F., Moad, C. L., Moad, G., et al. (1998) · Macromolecules · doi:10.1021/ma9804951 · Cited by 5,147
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Self-citationFormation of High-Quality CdTe, CdSe, and CdS Nanocrystals Using CdO as Precursor
Peng, Z. A., & Peng, X. (2001) · Journal of the American Chemical Society · doi:10.1021/ja003633m · Cited by 2,741
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Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant Protein
Mattoussi, H., Mauro, J. M., Goldman, E. R., Anderson, G. P., Sundar, V. C., Mikulec, F. V., & Bawendi, M. G. (2000) · Journal of the American Chemical Society · doi:10.1021/ja002535y · Cited by 1,681
Self-citationSelf-assembled nanoscale biosensors based on quantum dot FRET donors
Medintz, I. L., Clapp, A. R., Mattoussi, H., Goldman, E. R., Fisher, B., & Mauro, J. M. (2003) · Nature Materials · doi:10.1038/nmat961 · Cited by 1,601
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Cited by
Quantum dots in biomedical applications
Wagner, A. M., Knipe, J. M., Orive, G., & Peppas, N. A. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.022 · Cited by 632
Quantum dots as a platform for nanoparticle drug delivery vehicle design
Probst, C. E., Zrazhevskiy, P., Bagalkot, V., & Gao, X. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.036 · Cited by 466
Metadata
- Authors
- Liu, W., Greytak, A. B., Lee, J., Wong, C. R., Park, J., Marshall, L. F., Jiang, W., Curtin, P. N., Ting, A. Y., Nocera, D. G., Fukumura, D., Jain, R. K., & Bawendi, M. G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-12-21
- Volume
- 132
- Issue
- 2
- Pages
- 472-483
- ISSN
- 0002-7863
- 1520-5126
- OpenAlex
- W1986156969
- Cited by
- 278
- References
- 48
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
