The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Chiral Wedge Molecule Inhibits Telomerase Activity
Abstract
In addition to the Watson-Crick double helix, secondary DNA structures are thought to play important roles in a variety of biological processes. One important example is the G-quadruplex structure that is formed at the chromosome ends, which inhibits telomerase activity by blocking its access to telomeres. G-quadruplex structures represent a new class of molecular targets for DNA-interactive compounds that may be useful to target telomeres. Here, we reported the first example of enantioselective recognition of quadruplex DNA by a chiral cyclic helicene. We propose a new ligand-binding cleft between two telomeric human G-quadruplexes linked by a TTA linker. We found that the cyclic helicene M1 exhibited potent inhibitory activity against telomerase.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
McEachern, M. J., Krauskopf, A., & Blackburn, E. H. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.331 · Cited by 716
Cited by
One hundred years of helicene chemistry. Part 3: applications and properties of carbohelicenes
Gingras, M. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35134j · Cited by 931
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Self-citationXiong, J.-B., Feng, H.-T., Sun, J.-P., Xie, W.-Z., Yang, D., Liu, M., & Zheng, Y.-S. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07087 · Cited by 286
Metadata
- Authors
- Shinohara, K.-I., Sannohe, Y., Kaieda, S., Tanaka, K.-I., Osuga, H., Tahara, H., Xu, Y., Kawase, T., Bando, T., & Sugiyama, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-03-01
- Volume
- 132
- Issue
- 11
- Pages
- 3778-3782
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2092058466
- Cited by
- 207
- References
- 2
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shinohara, K.-I., Sannohe, Y., Kaieda, S., Tanaka, K.-I., Osuga, H., Tahara, H., Xu, Y., Kawase, T., Bando, T., & Sugiyama, H. (2010). A Chiral Wedge Molecule Inhibits Telomerase Activity. Journal of the American Chemical Society. https://doi.org/10.1021/ja908897j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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