The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.
Natural Products Version 2.0: Connecting Genes to Molecules
Open accessAbstract
Natural products have played a prominent role in the history of organic chemistry, and they continue to be important as drugs, biological probes, and targets of study for synthetic and analytical chemists. In this Perspective, we explore how connecting Nature's small molecules to the genes that encode them has sparked a renaissance in natural product research, focusing primarily on the biosynthesis of polyketides and non-ribosomal peptides. We survey monomer biogenesis, coupling chemistries from templated and non-templated pathways, and the broad set of tailoring reactions and hybrid pathways that give rise to the diverse scaffolds and functionalization patterns of natural products. We conclude by considering two questions: What would it take to find all natural product scaffolds? What kind of scientists will be studying natural products in the future?
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Cites
Items 201–237 of 237
Nagano, S., Li, H., Shimizu, H., Nishida, C. R., Ogura, H., de Montellano, P. R. O., & Poulos, T. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308115200 · Cited by 82
Ullrich, M. S., & Bender, C. L. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.24.7574-7586.1994 · Cited by 81
Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK
Lambalot, R. H., Cane, D. E., Aparicio, J. J., & Katz, L. (1995) · Biochemistry · doi:10.1021/bi00006a006 · Cited by 77
Calderone, C. T., Iwig, D. F., Dorrestein, P. C., Kelleher, N. L., & Walsh, C. T. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.06.008 · Cited by 74
Self-citationPolyketide‐Chain Branching by an Enzymatic Michael Addition
Kusebauch, B., Busch, B., Scherlach, K., Roth, M. M., & Hertweck, C. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900277 · Cited by 74
Rational Design and Assembly of Synthetic Trimodular Polyketide Synthases
Menzella, H. G., Carney, J. R., & Santi, D. V. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.12.002 · Cited by 73
Evolving biosynthetic tangos negotiate mechanistic landscapes
Austin, M. B., O’Maille, P. E., & Noel, J. P. (2008) · Nature Chemical Biology · doi:10.1038/nchembio0408-217 · Cited by 72
The enzymology of clavam and carbapenem biosynthesis
Kershaw, N. J., Caines, M. E. C., Sleeman, M. C., & Schofield, C. J. (2005) · Chemical Communications · doi:10.1039/b505964j · Cited by 67
Protein Assembly Line Components in Prodigiosin Biosynthesis: Characterization of PigA,G,H,I,J
Garneau‐Tsodikova, S., Dorrestein, P. C., Kelleher, N. L., & Walsh, C. T. (2006) · Journal of the American Chemical Society · doi:10.1021/ja063611l · Cited by 66
Self-citationSingh, S. B., Phillips, J. W., & Wang, J. (2007) · PubMed · Cited by 63
Genes and enzymes involved in bacterial isoprenoid biosynthesis
Daum, M., Herrmann, S., Wilkinson, B., & Bechthold, A. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.02.029 · Cited by 61
Quaderer, R., Ōmura, S., Ikeda, H., & Cane, D. E. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0639214 · Cited by 61
Watanabe, K., Hotta, K., Nakaya, M., Praseuth, A. P., Wang, C. C. C., Inada, D., Takahashi, K., Fukushi, E., Oguri, H., & Oikawa, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902261a · Cited by 60
Interactions between bacteria and eukaryotes via small molecules
Dudler, R., & Eberl, L. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.04.004 · Cited by 58
Kruger, R. G., Lü, W., Oberthür, M., Tao, J., Kahne, D. E., & Walsh, C. T. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.12.005 · Cited by 57
Self-citationAnalysis of the Indanomycin Biosynthetic Gene Cluster from Streptomyces antibioticus NRRL 8167
Li, C., Roege, K. E., & Kelly, W. L. (2009) · ChemBioChem · doi:10.1002/cbic.200800822 · Cited by 56
A Latent Oxazoline Electrophile for N−O−C Bond Formation in Pseudomonine Biosynthesis
Sattely, E. S., & Walsh, C. T. (2008) · Journal of the American Chemical Society · doi:10.1021/ja804499r · Cited by 56
Self-citationIteratively Acting Glycosyltransferases Involved in the Hexasaccharide Biosynthesis of Landomycin A
Luzhetskyy, A. N., Fedoryshyn, M., Dürr, C., Taguchi, T., Novikov, V. P., & Bechthold, A. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.05.008 · Cited by 56
New reactions in clavulanic acid biosynthesis
Townsend, C. A. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00392-7 · Cited by 55
Indolocarbazole antitumour compounds by combinatorial biosynthesis
Salas, J. A., & Méndez, C. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.02.003 · Cited by 54
Thulasiram, H. V., Erickson, H. K., & Poulter, C. D. (2008) · Journal of the American Chemical Society · doi:10.1021/ja0771282 · Cited by 49
O'Connor, S. E., Chen, H., & Walsh, C. T. (2002) · Biochemistry · doi:10.1021/bi020006w · Cited by 47
Self-citationFeatures and applications of bacterial glycosyltransferases: current state and prospects
Luzhetskyy, A. N., & Bechthold, A. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1672-2 · Cited by 45
Shi, R., Lamb, S. S., Zakeri, B., Proteau, A., Cui, Q., Sulea, T. I., Matte, A., Wright, G. D., & Cygler, M. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.02.007 · Cited by 43
Nanomole-scale natural products discovery.
Molinski, T. F. (2009) · PubMed · Cited by 38
Kumar, P., Li, Q., Cane, D. E., & Khosla, C. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0297537 · Cited by 38
Woithe, K., Geib, N., Meyer, O., Wörtz, T., Zerbe, K., & Robinson, J. A. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b805956j · Cited by 35
Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
You, Z., Ōmura, S., Ikeda, H., Cane, D. E., & Jogl, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706358200 · Cited by 33
Vinayavekhin, N., & Saghatelian, A. (2009) · ACS Chemical Biology · doi:10.1021/cb900075n · Cited by 33
Amide N-Glycosylation by Asm25, an N-Glycosyltransferase of Ansamitocins
Zhao, P., Bai, L., Ma, J., Zeng, Y., Li, L., Zhang, Y., Lu, C., Dai, H., Wu, Z., Li, Y., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.06.007 · Cited by 31
Architectural self-construction in nature and chemical synthesis
Sorensen, E. J. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(03)00185-8 · Cited by 31
Biosynthesis of polyoxypeptin A: novel amino acid 3-hydroxy-3-methylproline derived from isoleucine
Umezawa, K., Ikeda, Y., Kawase, O., NAGANAWA, H., & Kondo, S. (2001) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/b101942m · Cited by 29
Recent advances in the biosynthetic studies of lovastatin.
Sutherland, A. J., Auclair, K., & Vederas, J. C. (2001) · PubMed · Cited by 28
Howard‐Jones, A. R., Kruger, R. G., Lü, W., Tao, J., Leimkuhler, C., Kahne, D. E., & Walsh, C. T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0735857 · Cited by 27
Self-citationRobbel, L., Hoyer, K. M., & Marahiel, M. A. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06897.x · Cited by 26
Kelly, W. L., Hillson, N. J., & Walsh, C. T. (2005) · Biochemistry · doi:10.1021/bi051124x · Cited by 26
Self-citationExtending the Biosynthetic Repertoire in Ribosomal Peptide Assembly
Moore, B. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803868 · Cited by 12
Cited by
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.034 · Cited by 981
Self-citationChemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
Kusari, S., Hertweck, C., & Spiteller, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.06.004 · Cited by 743
Modulators of Protein–Protein Interactions
Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews · doi:10.1021/cr400698c · Cited by 497
Actinomycetes: Still a source of novel antibiotics
Genilloud, O. (2017) · Natural Product Reports · doi:10.1039/c7np00026j · Cited by 465
Molecular mechanisms of antibiotic resistance
Wright, G. D. (2011) · Chemical Communications · doi:10.1039/c0cc05111j · Cited by 443
Metadata
- Authors
- Walsh, C. T., & Fischbach, M. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-02-01
- Volume
- 132
- Issue
- 8
- Pages
- 2469-2493
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2037026236
- Cited by
- 468
- References
- 237
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- green
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