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Direct Observation of Hydrogen Bonds in Nucleic Acid Base Pairs by Internucleotide 2JNN Couplings
Abstract
Hydrogen bonds play a key role in the stabilization of protein and nucleic acid secondary structure. Currently, most of the experimental evidence for the interaction of hydrogen bond donor and acceptor atoms is indirect. Here we show that scalar couplings across the hydrogen bond are observable for Watson−Crick base pairs in 15 N-labeled RNA. These scalar couplings correlate the imino donor 15 N nucleus and the corresponding acceptor 15 N nucleus on the complementary base. The two-bond J NN couplings between the N3 of uridine and the N1 of adenosine, and between the N1 of guanosine and the N3 of cytidine, have values of approximately 7 Hz as determined by a novel quantitative J -correlation experiment for the 69-nucleotide T1 domain of the potato spindle tuber viroid. In contrast, for non-Watson−Crick base pairs the hydrogen bond acceptor is usually not a nitrogen, but an oxygen atom, and thus, the two-bond J NN couplings are not observed.
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Cited by
Defining the hydrogen bond: An account (IUPAC Technical Report)
Arunan, E., Desiraju, G. R., Klein, R. A., Sadlej, J., Scheiner, S., Alkorta, I., Clary, D. C., Crabtree, R. H., Dannenberg, J. J., Hobza, P., et al. (2011) · Pure and Applied Chemistry · doi:10.1351/pac-rep-10-01-01 · Cited by 1,021
Hydrogen Bonding in DNA Base Pairs: Reconciliation of Theory and Experiment
Fonseca Guerra, C., Bickelhaupt, F. M., Snijders, J. G., & Baerends, E. J. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993262d · Cited by 448
Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction
Phan, A. T., Kuryavyi, V., Darnell, J. C., Serganov, A., Majumdar, A., Ilin, S., Raslin, T., Polonskaia, A., Chen, C., Clain, D., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2064 · Cited by 257
MARIS, C., MASSE, J., CHESTER, A., NAVARATNAM, N., & ALLAIN, F. H.-T. (2005) · RNA · doi:10.1261/rna.7190705 · Cited by 50
Dehner, A., Planker, E., Gemmecker, G., Broxterman, Q. B., Bisson, W., Formaggio, F., Crisma, M., Toniolo, C., & Kessler, H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010635d · Cited by 40
Metadata
- Authors
- Dingley, A. J., & Grzesiek, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-08-01
- Volume
- 120
- Issue
- 33
- Pages
- 8293-8297
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2094342137
- Cited by
- 626
- References
- 0
- FWCI
- 29.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Direct Observation of Hydrogen Bonds in Nucleic Acid Base Pairs by Internucleotide 2JNN Couplings. https://app.cochat.ai/papers/10.1021/ja981513x
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- Dingley, A. J., & Grzesiek, S. (1998). Direct Observation of Hydrogen Bonds in Nucleic Acid Base Pairs by Internucleotide 2JNN Couplings. Journal of the American Chemical Society. https://doi.org/10.1021/ja981513x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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