The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia
Open accessAbstract
Despite the clinical success of photodynamic therapy (PDT), the application of this medical technique is intrinsically limited by the low oxygen concentrations found in cancer tumors, hampering the production of therapeutically necessary singlet oxygen ( 1 O 2 ). To overcome this limitation, we report on a novel mitochondria-localized iridium(III) endoperoxide prodrug ( 2-O-IrAn ), which, upon two-photon irradiation in NIR, synergistically releases a highly cytotoxic iridium(III) complex ( 2-IrAn ), singlet oxygen, and an alkoxy radical. 2-O-IrAn was found to be highly (photo-)toxic in hypoxic tumor cells and multicellular tumor spheroids (MCTS) in the nanomolar range. To provide cancer selectivity and improve the pharmacological properties of 2-O-IrAn, it was encapsulated into a biotin-functionalized polymer. The generated nanoparticles were found to nearly fully eradicate the tumor inside a mouse model within a single treatment. This study presents, to the best of our knowledge, the first example of an iridium(III)-based endoperoxide prodrug for synergistic photodynamic therapy/photoactivated chemotherapy, opening up new avenues for the treatment of hypoxic tumors.
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Citations
Cites
Singlet Oxygen “Afterglow” Therapy with NIR‐II Fluorescent Molecules
Zou, J., Li, L., Zhu, J., Li, X., Yang, Z., Huang, W., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202103627 · Cited by 155
Cited by
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Li, C., Pang, Y., Xu, Y., Lu, M., Tu, L., Li, Q., Sharma, A., Guo, Z., Li, X., & Sun, Y. (2023) · Chemical Society Reviews · doi:10.1039/d3cs00227f · Cited by 157
Metadata
- Authors
- Kuang, S., Wei, F., Karges, J., Ke, L., Xiong, K., Liao, X., Gasser, G., Ji, L., & Chao, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-02-16
- Volume
- 144
- Issue
- 9
- Pages
- 4091-4101
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W4212772959
- Cited by
- 271
- References
- 1
- FWCI
- 31.01
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia. https://app.cochat.ai/papers/10.1021/jacs.1c13137
- The paper
- Kuang, S., Wei, F., Karges, J., Ke, L., Xiong, K., Liao, X., Gasser, G., Ji, L., & Chao, H. (2022). Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.1c13137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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