Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications
Abstract
Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier to their distribution, therapeutic action, visual tracking, and efficacy evaluation.
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Current design strategies to achieve redshifts in metal complexes can be categorized into five main approaches: structural modulation of tetrapyrrolic complexes; coordination of metals to predesigned NIR-absorbing ligands; fine-tuning of metal-metal interactions; construction of coordination polymers; and molecular engineering of bis(dithiolene) complexes.
“Current design strategies to achieve redshifts can be categorized into five main approaches: (i) structural modulation of tetrapyrrolic complexes; (ii) coordination of metals to predesigned NIR-absorbing ligands; (iii) fine-tuning of metal-metal interactions; (iv) construction of coordination polymers; and (v) molecular engineering of bis(dithiolene) complexes200.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [200]
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References 328 · Cited by 157
- Authors
- Li, C., Pang, Y., Xu, Y., Lu, M., Tu, L., Li, Q., Sharma, A., Guo, Z., Li, X., & Sun, Y.
- Affiliations
- Central China Normal University (CN)
- Guizhou University (CN)
- NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
- Central Scientific Instruments Organisation (IN)
- Wuhan University of Science and Technology (CN)
- Corresponding author
- Guo, Zhenzhong
- Li, Xiangyang
- Sun, Yao
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 52
- Issue
- 13
- Pages
- 4392-4442
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W4381232753
- Cited by
- 157
- References
- 328
- Citations by year
- 2026: 27 · 2025: 53 · 2024: 62 · 2023: 15
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-07-12)
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (22022404, 22074050, 81973097, 32172461)
- National Key Research and Development Program of China (2021YFA0716702)
- Fundamental Research Funds for the Central Universities (CCNU22QN010)
- State Key Laboratory of Virology (2022KF002)
- State Key Laboratory of Biocatalysis and Enzyme Engineering (20220015)
- Wuhan University of Science and Technology (OHIC2022K02)
- Department of Biotechnology, Ministry of Science and Technology, India (BT/RLF/Re-entry/59/2018)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- NIR-II imaging, metal-organic frameworks, metal-organic complexes, photophysical properties, bioimaging, photothermal therapy, deep tissue penetration, precision medicine, molecular design strategy
- MeSH terms
- Diagnostic Imaging, Fluorescent Dyes, Metals, Precision Medicine, Optical Imaging
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