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PEGylated N -Heterocyclic Carbene Anchors Designed To Stabilize Gold Nanoparticles in Biologically Relevant Media
Abstract
N-Heterocyclic carbenes (NHCs) have emerged as versatile ligands for surface functionalization. Their ease of synthesis and ability to form strong bonds with a range of substrates provide a unique complement to traditional surface modification methods. Gold nanoparticles (NPs) are a particularly useful class of materials whose applications intimately depend on surface functionalization. Here we report the development of PEGylated-NHC ligands for Au-NP surfaces and the first example of NHC-functionalized NPs that are compatible with biologically relevant conditions. Our PEGylated-NHC-Au-NPs are stable toward aggregation in aqueous solutions in the pH range of 3-14, in <250 mM electrolyte solutions, at high and low temperatures (95 and -78 °C), in cell culture media, and in aqueous H2O2 solutions. This work demonstrates for the first time that NHCs can serve as anchors for water-soluble Au-NPs and opens the door to potential biomedical applications of NHC surface anchors.
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Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
Zhukhovitskiy, A. V., MacLeod, M. J., & Johnson, J. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00220 · Cited by 363
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Metadata
- Authors
- MacLeod, M. J., & Johnson, J. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-06-17
- Volume
- 137
- Issue
- 25
- Pages
- 7974-7977
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2472551131
- Cited by
- 215
- References
- 1
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacLeod, M. J., & Johnson, J. A. (2015). PEGylated N -Heterocyclic Carbene Anchors Designed To Stabilize Gold Nanoparticles in Biologically Relevant Media. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b02452
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