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A Rationally Designed Upconversion Nanoprobe for in Vivo Detection of Hydroxyl Radical
Abstract
The detection of •OH in live organisms is crucial to the understanding of its physiological and pathological roles; while this is too challenging because of the extremely low concentration and high reactivity of the species in the body. Herein, we report the rational design and fabrication of an NIR-light excited luminescence resonance energy transfer-based nanoprobe, which for the first time realizes the in vivo detection of •OH. The nanoprobe is composed of two moieties: upconversion nanoparticles with sandwich structure and bared surface as the energy donor; and mOG, a modified azo dye with tunable light absorption, as both the energy acceptor and the •OH recognizing ligand. The as-constructed nanoprobe exhibited ultrahigh sensitivity (with the quantification limit down to 1.2 femtomolar, several orders of magnitude lower than that of most previous •OH probes), good biocompatibility, and specificity. It was successfully used for monitoring [•OH] levels in live cells and tissues.
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Inflammasomes in health and disease
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H 2 O 2 , a Necessary Evil for Cell Signaling
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Rare-Earth Doping in Nanostructured Inorganic Materials
Zheng, B., Fan, J., Chen, B., Qin, X., Wang, J., Wang, F., Deng, R., & Liu, X. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00644 · Cited by 1,204
Gu, B., & Zhang, Q. (2018) · Advanced Science · doi:10.1002/advs.201700609 · Cited by 292
Nitroxidative signaling mechanisms in pathological pain
Grace, P. M., Gaudet, A. D., Staikopoulos, V., Maier, S. F., Hutchinson, M. R., Salvemini, D., & Watkins, L. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.003 · Cited by 128
Metadata
- Authors
- Li, Z., Liang, T., Lv, S., Zhuang, Q., & Liu, Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-08-24
- Volume
- 137
- Issue
- 34
- Pages
- 11179-11185
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1172910237
- Cited by
- 184
- References
- 4
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Z., Liang, T., Lv, S., Zhuang, Q., & Liu, Z. (2015). A Rationally Designed Upconversion Nanoprobe for in Vivo Detection of Hydroxyl Radical. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b06972
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