H + Ions and ATP Reshape the Conformational Landscape of an RNA Recognition Motif and Regulate Its Fibrillation

Highly accurate protein structure prediction with AlphaFold

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The Protein-Folding Problem, 50 Years On

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ATP as a biological hydrotrope

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

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Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation

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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation

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Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

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Detecting transient intermediates in macromolecular binding by paramagnetic NMR

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Characterization of the Dynamics of Biomacromolecules Using Rotating-Frame Spin Relaxation NMR Spectroscopy

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Scalable emulation of protein equilibrium ensembles with generative deep learning

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POKY: a software suite for multidimensional NMR and 3D structure calculation of biomolecules

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An Improved 15N Relaxation Dispersion Experiment for the Measurement of Millisecond Time-Scale Dynamics in Proteins

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Two-Dimensional NMR Lineshape Analysis

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Extending the range of amide proton relaxation dispersion experiments in proteins using a constant-time relaxation-compensated CPMG approach

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Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer

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Off-Resonance R1ρ NMR Studies of Exchange Dynamics in Proteins with Low Spin-Lock Fields: An Application to a Fyn SH3 Domain

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Protein conformational ensembles in function: roles and mechanisms

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NMR studies of structure and function of biological macromolecules (Nobel Lecture)*

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One, Two, Three, Four! How Multiple RRMs Read the Genome Sequence

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HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

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Effects of pH alterations on stress- and aging-induced protein phase separation

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ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain

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The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site

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Probing Slow Protein Dynamics by Adiabatic R1ρ and R2ρ NMR Experiments

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RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

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Evidence for Many Unique Solution Structures for Chymotrypsin Inhibitor 2: A Thermodynamic Perspective Derived from vT-ESI-IMS-MS Measurements

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Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

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RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation

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NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations

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NMR methods for exploring ‘dark’ states in ligand binding and protein-protein interactions

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Amyotrophic Lateral Sclerosis, FUS and Protein Synthesis Defects

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Progress in protein crystallography

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Heteronuclear Adiabatic Relaxation Dispersion (HARD) for quantitative analysis of conformational dynamics in proteins

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ATP Kinetically Modulates Pathogenic Tau Fibrillations

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Inherent conformational plasticity in dsRBDs enables interaction with topologically distinct RNAs

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Adenosine triphosphate induces amorphous aggregation of amyloid β by increasing Aβ dynamics

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Observation of Continuous Contraction and a Metastable Misfolded State during the Collapse and Folding of a Small Protein

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Optimizing frequency sampling in CEST experiments

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Elucidating ATP’s role as solubilizer of biomolecular aggregatePreprint

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ATP modulates self-perpetuating conformational conversion generating structurally distinct yeast prion amyloids that limit autocatalytic amplification

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Connecting Protein Millisecond Conformational Dynamics to Protein Thermal Stability

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Understanding the Impacts of Conformational Dynamics on the Regulation of Protein–Protein Association by a Multiscale Simulation Method

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Conformational Plasticity in dsRNA-Binding Domains Drives Functional Divergence in RNA Recognition.

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Mapping the Conformational Heterogeneity Intrinsic to the Protein Native Ensemble

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Investigating the role of conformational heterogeneity in FUS-RRM fibrillation

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Investigating the role of conformational heterogeneity in FUS-RRM fibrillation

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ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain

Kang, J., Lim, L., & Song, J. (2019) · Communications Biology · doi:10.1038/s42003-019-0463-x · Cited by 85 · see citing works

ATP is a cryptic binder of TDP-43 RRM domains to enhance stability and inhibit ALS/AD-associated fibrillation

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RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

Lu, Y., Lim, L., & Song, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01281-7 · Cited by 58 · see citing works

BPS2026 – Synergistic role of RGG2 in modulating FUS RRM structure and RNA binding revealed by enhanced sampling simulations

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