The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus
Open accessPublished version of a preprint
Abstract
High Resolution Image Download MS PowerPoint Slide We report the synthesis and characterization of a small molecule, CP-20, capable of inhibiting the key quorum sensing receptor AgrC in Staphylococcus aureus . Structural alterations enabled the discovery of a CP-20 derivative that is capable of complete quorum sensing inhibition with mid-nanomolar potency. In vitro biochemical investigations support CP-20 binding AgrC and competitively inhibiting its activity. CP-20 represents a versatile and synthetically tractable small molecule probe for investigating Staphylococcal virulence via quorum sensing modulation.
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Research works printed but not linked: 1
- Corso, G.; Stärk, H.; Jing, B.; Barzilay, R.; Jaakkola, T., DiffDock: Diffusion Steps, Twists, and Turns for Molecular Docking. In International Conference on Learning Representations (ICLR) , 2023.
Metadata
- Authors
- Polaske, T. J., Vulpis, T. D., Nelson, A. E., Zhao, K., & Blackwell, H. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Blackwell, Helen E.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2026-02-23
- Volume
- 148
- Issue
- 9
- Pages
- 9199-9204
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W7131109821
- Cited by
- 3
- References
- 43
- Citations by year
- 2026: 3
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American Chemical Society (publishedVersion, cc-by)
- ChemRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Division of Chemistry (CHE-2108511, CHE-2516357)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- quorum sensing inhibition, Staphylococcus aureus, chemical probes, competitive inhibition, receptor binding
- MeSH terms
- Anti-Bacterial Agents, Bacterial Proteins, Protein Kinases, Staphylococcus aureus, Molecular Structure, Quorum Sensing, Small Molecule Libraries
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- CoChat. (2026). Citation check: A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus. https://app.cochat.ai/papers/10.1021/jacs.5c21051
- The paper
- Polaske, T. J., Vulpis, T. D., Nelson, A. E., Zhao, K., & Blackwell, H. E. (2026). A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5c21051
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
