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Cited by 398

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells

Deng, Jingjing, Wang, Kai, Wang, Ming, Yu, Ping, Mao, Lanqun·2017·Journal of the American Chemical Society

Abstract

Zeolitic imidazole frameworks (ZIFs) are an emerging class of functional porous materials with promising biomedical applications such as molecular sensing and intracellular drug delivery. We report herein the first example of using nanoscale ZIFs (i.e., ZIF-90), self-assembled from Zn 2+ and imidazole-2-carboxyaldehyde, to target subcellular mitochondria and image dynamics of mitochondrial ATP in live cells. Encapsulation of fluorescent Rhodamine B (RhB) into ZIF-90 suppresses the emission of RhB, while the competitive coordination between ATP and the metal node of ZIF-90 dissembles ZIFs, resulting in the release of RhB for ATP sensing. With this method, we are able to image mitochondrial ATP in live cells and study the ATP level fluctuation in cellular glycolysis and apoptosis processes. The strategy reported here could be further extended to tune nanoscale ZIFs inside live cells for targeted delivery of therapeutics to subcellular organelles for advanced biomedical applications.

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Metadata

Authors
Deng, J., Wang, K., Wang, M., Yu, P., & Mao, L.
Venue
Journal of the American Chemical Society
Published
2017-04-14
Volume
139
Issue
16
Pages
5877-5882
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2604582212
Cited by
398
References
45
FWCI
12.07
Type
journal article
Language
en
Open access
closed

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