The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms
Open accessAbstract
The rapid emergence of antibiotic-resistant bacterial "superbugs" with concomitant treatment failure and high mortality rates presents a severe threat to global health. The superbug risk is further exacerbated by chronic infections generated from antibiotic-resistant biofilms that render them refractory to available treatments. We hypothesized that efficient antimicrobial agents could be generated through careful engineering of hydrophobic and cationic domains in a synthetic semirigid polymer scaffold, mirroring and amplifying attributes of antimicrobial peptides. We report the creation of polymeric nanoparticles with highly efficient antimicrobial properties. These nanoparticles eradicate biofilms with low toxicity to mammalian cells and feature unprecedented therapeutic indices against red blood cells. Most notably, bacterial resistance toward these nanoparticles was not observed after 20 serial passages, in stark contrast to clinically relevant antibiotics where significant resistance occurred after only a few passages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antibiotic resistance-the need for global solutions
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70318-9 · Cited by 4,439
Polymeric materials with antimicrobial activity
Muñoz-Bonilla, A., & Fernández-García, M. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.005 · Cited by 1,221
Mixed‐species biofilm compromises wound healing by disrupting epidermal barrier function
Roy, S., Elgharably, H., Sinha, M., Ganesh, K., Chaney, S., Mann, E., Miller, C., Khanna, S., Bergdall, V. K., Powell, H. M., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4360 · Cited by 208
Cited by
Combatting antibiotic-resistant bacteria using nanomaterials
Gupta, A., Mumtaz, S., Li, C.-H., Hussain, I., & Rotello, V. M. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00748e · Cited by 1,115
Self-citationSynergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives
Hu, X., Zhang, H., Wang, Y., Shiu, B.-C., Lin, J.-H., Zhang, S., Lou, C.-W., & Li, T.-T. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138129 · Cited by 365
Zhou, T., Hu, R., Wang, L., Qiu, Y., Zhang, G., Deng, Q., Zhang, H., Yin, P., Situ, B., Zhan, C., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916704 · Cited by 265
Metadata
- Authors
- Gupta, A., Landis, R. F., Li, C.-H., Schnurr, M., Das, R., Lee, Y.-W., Yazdani, M., Liu, Y., Kozlova, A., & Rotello, V. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-08-31
- Volume
- 140
- Issue
- 38
- Pages
- 12137-12143
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2889241777
- Cited by
- 173
- References
- 3
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms. https://app.cochat.ai/papers/10.1021/jacs.8b06961
- The paper
- Gupta, A., Landis, R. F., Li, C.-H., Schnurr, M., Das, R., Lee, Y.-W., Yazdani, M., Liu, Y., Kozlova, A., & Rotello, V. M. (2018). Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.8b06961
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
