The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enzyme Encapsulation in a Porous Hydrogen-Bonded Organic Framework
Abstract
Protection of biological assemblies is critical to applications in biotechnology, increasing the durability of enzymes in biocatalysis or potentially stabilizing biotherapeutics during transport and use. Here we show that a porous hydrogen-bonded organic framework (HOF) constructed from water-soluble tetra-amidinium ( 1· Cl 4 ) and tetracarboxylate ( 2 ) building blocks can encapsulate and stabilize biomolecules to elevated temperature, proteolytic and denaturing agents, and extend the operable pH range for catalase activity. The HOF, which readily retains water within its framework structure, can also protect and retain the activity of enzymes such as alcohol oxidase, that are inactive when encapsulated within zeolitic imidazolate framework (ZIF) materials. Such HOF coatings could provide valid alternative materials to ZIFs: they are metal free, possess larger pore apertures, and are stable over a wider, more biologically relevant pH range.
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Error bars in experimental biology
Cumming, G., Fidler, F., & Vaux, D. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611141 · Cited by 940
Cited by
Hydrogen-Bonded Organic Frameworks as a Tunable Platform for Functional Materials
Wang, B., Lin, R.-B., Zhang, Z., Xiang, S., & Chen, B. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c06473 · Cited by 852
Metal–Organic Framework-Based Enzyme Biocomposites
Liang, W., Wied, P., Carraro, F., Sumby, C. J., Nidetzky, B., Tsung, C.-K., Falcaro, P., & Doonan, C. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01029 · Cited by 784
Self-citationHydrogen-bonded organic frameworks: Chemistry and functions
Lin, R.-B., & Chen, B. (2022) · Chem · doi:10.1016/j.chempr.2022.06.015 · Cited by 485
Metadata
- Authors
- Liang, W., Carraro, F., Solomon, M. B., Bell, S. G., Amenitsch, H., Sumby, C. J., White, N. G., Falcaro, P., & Doonan, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-08-19
- Volume
- 141
- Issue
- 36
- Pages
- 14298-14305
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2969524404
- Cited by
- 387
- References
- 1
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, W., Carraro, F., Solomon, M. B., Bell, S. G., Amenitsch, H., Sumby, C. J., White, N. G., Falcaro, P., & Doonan, C. J. (2019). Enzyme Encapsulation in a Porous Hydrogen-Bonded Organic Framework. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.9b06589
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